Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis.
Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis.
复制标题
使用系统生物学发现的细胞周期基因表达网络：癌变中的重要性。
DOI：
10.1002/jcp.24990
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发表时间：
2015-10
影响因子：
5.6
通讯作者：
Stein, Gary S.
中科院分区：
文献类型：
--
作者：
Scott, Robert E.;Ghule, Prachi N.;Stein, Janet L.;Stein, Gary S.
The early stages of carcinogenesis are linked to defects in the cell cycle. A series of cell cycle checkpoints are involved in this process. The G1/S checkpoint that serves to integrate the control of cell proliferation and differentiation is linked to carcinogenesis and the mitotic spindle checkpoint with the development of chromosomal instability. This paper presents the outcome of systems biology studies designed to evaluate if networks of covariate cell cycle gene transcripts exist in proliferative mammalian tissues including mice, rats and humans. The GeneNetwork website that contains numerous gene expression datasets from different species, sexes and tissues represents the foundational resource for these studies (www.genenetwork.org). In addition, WebGestalt, a gene ontology tool, facilitated the identification of expression networks of genes that co-vary with key cell cycle targets, especially Cdc20 and Plk1 (www.bioinfo.vanderbilt.edu/webgestalt). Cell cycle expression networks of such covariate mRNAs exist in multiple proliferative tissues including liver, lung, pituitary, adipose and lymphoid tissues among others but not in brain or retina that have low proliferative potential. Sixty-three covariate cell cycle gene transcripts (mRNAs) compose the average cell cycle network with p = e−13 to e−36. Cell cycle expression networks show species, sex and tissue variability and they are enriched in mRNA transcripts associated with mitosis many of which are associated with chromosomal instability.
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影响因子：
5.6
作者：
de Oliveira Dal'Molin CG;Orellana C;Gebbie L;Steen J;Hodson MP;Chrysanthopoulos P;Plan MR;McQualter R;Palfreyman RW;Nielsen LK
通讯作者：
Nielsen LK
影响因子：
5.6
作者：
Kapinas, Kristina;Kim, Heesun;Mandeville, Matthew;Martin-Buley, Lori A.;Croce, Carlo M.;Lian, Jane B.;Van Wijnen, Andre J.;Stein, Janet L.;Altieri, Dario C.;Stein, Gary S.
通讯作者：
Stein, Gary S.
影响因子：
56.9
作者：
de Lichtenberg, U;Jensen, LJ;Bork, P
通讯作者：
Bork, P
影响因子：
5.6
作者：
Aguilar, Rodrigo;Grandy, Rodrigo;Meza, Daniel;Sepulveda, Hugo;Pihan, Philippe;van Wijnen, Andre J.;Lian, Jane B.;Stein, Gary S.;Stein, Janet L.;Montecino, Martin
通讯作者：
Montecino, Martin
DOI：
10.1073/pnas.0809273105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Ghule, Prachi N.;Dominski, Zbigniew;Stein, Gary S.
通讯作者：
Stein, Gary S.