Age-specific modifiable risk factor profiles for cardiovascular disease and all-cause mortality: a nationwide, population-based, prospective cohort study.
Age-specific modifiable risk factor profiles for cardiovascular disease and all-cause mortality: a nationwide, population-based, prospective cohort study.
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心血管疾病和全因死亡率的特定年龄可改变危险因素概况：一项全国性、基于人群的前瞻性队列研究
DOI：
10.1016/j.lanwpc.2021.100277
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Wang T;Zhao Z;Yu X;Zeng T;Xu M;Xu Y;Hu R;Chen G;Su Q;Mu Y;Chen L;Tang X;Yan L;Qin G;Wan Q;Gao Z;Wang G;Shen F;Luo Z;Qin Y;Chen L;Huo Y;Li Q;Ye Z;Zhang Y;Liu C;Wang Y;Wu S;Yang T;Deng H;Zhao J;Xu Y;Li M;Chen Y;Wang S;Ning G;Bi Y;Shi L;Lu J;Wang W
在中国，关于心血管疾病（CVD）和死亡率的年龄特异性可变风险因素特征的国家调查很少，中国正在经历人口老龄化加剧的巨大心脏代谢负担。这是一项在中国心脏代谢疾病和癌症队列研究（2011-2016）中纳入193，846名成人的全国性前瞻性队列研究。在139，925名基线时无CVD的参与者中，我们检查了4个年龄组（40-<55岁，55-<65岁，65-<75岁和≥75岁）CVD和归因于12个可改变的社会经济，心理社会，生活方式和代谢风险因素的全因死亡率的风险比和人群归因风险百分比（PAR%s）。在40-<55岁、55-<65岁和65-<75岁的参与者中，代谢危险因素分别占CVD事件PAR%的52.4%、47.2%和37.8%，其中高血压是最大的危险因素。而在≥75岁的受试者中，生活方式危险因素对CVD的PAR%的贡献率为34.0%，其中睡眠时间不适当是主要危险因素。在40-<55岁的参与者中，大多数死亡归因于代谢危险因素（PAR% 25·3%）和生活方式危险因素（PAR% 24·6%），不健康的饮食和糖尿病是主要危险因素。而在年龄≥55岁的参与者中，大多数死亡归因于生活方式风险因素（PAR% 26.6%-41.0%）和社会经济和心理社会风险因素（PAR% 26.1%-27.7%）。在年龄≥75岁的参与者中，生活方式风险因素占死亡率PAR%的41.0%，其中睡眠时间不适当是主要风险因素。我们确定了中国成年人CVD和全因死亡率的年龄特异性可变风险特征，≥75岁的成年人与年轻人之间存在显著差异。国家自然科学基金委员会.
National investigations on age-specific modifiable risk factor profiles for cardiovascular disease (CVD) and mortality are scarce in China, the country that is experiencing a huge cardiometabolic burden exacerbated by population ageing. This is a nationwide prospective cohort study of 193,846 adults in the China Cardiometabolic Disease and Cancer Cohort Study, 2011-2016. Among 139,925 participants free from CVD at baseline, we examined hazard ratios and population-attributable risk percentages (PAR%s) for CVD and all-cause mortality attributable to 12 modifiable socioeconomic, psychosocial, lifestyle, and metabolic risk factors by four age groups (40-<55 years, 55-<65 years, 65-<75 years, and ≥75 years). Metabolic risk factors accounted for 52·4%, 47·2%, and 37·8% of the PAR% for CVD events in participants aged 40-<55 years, 55-<65 years, and 65-<75 years, respectively, with hypertension being the largest risk factor. While in participants aged ≥75 years, lifestyle risk factors contributed to 34·0% of the PAR% for CVD, with inappropriate sleep duration being the predominant risk factor. Most deaths were attributed to metabolic risk factors (PAR% 25·3%) and lifestyle risk factors (PAR% 24·6%) in participants aged 40-<55 years, with unhealthy diet and diabetes being the main risk factors. While in participants aged ≥55 years, most deaths were attributed to lifestyle risk factors (PAR% 26·6%-41·0%) and socioeconomic and psychosocial risk factors (PAR% 26·1%-27·7%). In participants aged ≥75 years, lifestyle risk factors accounted for 41·0% of the PAR% for mortality, with inappropriate sleep duration being the leading risk factor. We identified age-specific modifiable risk profiles for CVD and all-cause mortality in Chinese adults, with remarkable differences between adults aged ≥75 years and their younger counterparts. National Natural Science Foundation of China.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
睡眠持续时间与全因死亡率和心血管事件的关系：前瞻性队列研究的系统回顾和剂量反应荟萃分析
影响因子：
5.4
作者：
Yin J;Jin X;Shan Z;Li S;Huang H;Li P;Peng X;Peng Z;Yu K;Bao W;Yang W;Chen X;Liu L
通讯作者：
Liu L
DOI：
10.1016/s0140-6736(20)30925-9
发表时间：
2020-10-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2019 Diseases and Injuries Collaborators
通讯作者：
GBD 2019 Diseases and Injuries Collaborators
影响因子：
168.9
作者：
Lu, Jiapeng;Lu, Yuan;Jiang, Lixin
通讯作者：
Jiang, Lixin
影响因子：
2.3
作者：
Spiegelman, D.;Hertzmark, E.;Wand, H. C.
通讯作者：
Wand, H. C.