Gene-environment interactions and intermediate phenotypes: early trauma and depression.
Gene-environment interactions and intermediate phenotypes: early trauma and depression.
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DOI：
10.3389/fendo.2014.00014
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发表时间：
2014
影响因子：
5.2
通讯作者：
Heim CM
中科院分区：
文献类型：
--
作者：
Hornung OP;Heim CM
本文就早期生活应激(ELS)相互作用与抑郁症的基因研究进展作一综述。ELS是指儿童和青少年时期令人厌恶的经历，如性虐待、身体虐待或情感虐待、情感或身体忽视以及父母失去亲人。以往的研究集中于研究和表征ELS在抑郁症发病机制中的具体作用，并将这些发现与大脑的神经生物学变化，特别是应激反应系统联系起来。最新的发现强调了遗传因素的作用，这些因素增加了儿童创伤后的脆弱性，或者同样地提高了对抑郁的韧性。考虑中间表型进一步加深了我们对早期创伤和抑郁之间复杂关系的理解。关于儿童时期不良环境事件造成的表观遗传变化的最新发现，促进了目前为ELS长期影响的预防和治疗计划确定具体目标领域的努力。综上所述，最新的研究结果强调了基因型和表观遗传过程在儿童创伤后抑郁症发展中的重要作用，从而为未来的研究和临床干预奠定了基础。
This review focuses on current research developments in the study of gene by early life stress (ELS) interactions and depression. ELS refers to aversive experiences during childhood and adolescence such as sexual, physical or emotional abuse, emotional or physical neglect as well as parental loss. Previous research has focused on investigating and characterizing the specific role of ELS within the pathogenesis of depression and linking these findings to neurobiological changes of the brain, especially the stress response system. The latest findings highlight the role of genetic factors that increase vulnerability or, likewise, promote resilience to depression after childhood trauma. Considering intermediate phenotypes has further increased our understanding of the complex relationship between early trauma and depression. Recent findings with regard to epigenetic changes resulting from adverse environmental events during childhood promote current endeavors to identify specific target areas for prevention and treatment schemes regarding the long-term impact of ELS. Taken together, the latest research findings have underscored the essential role of genotypes and epigenetic processes within the development of depression after childhood trauma, thereby building the basis for future research and clinical interventions.
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DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
120.7
作者：
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通讯作者：
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影响因子：
3.7
作者：
Binder, E. B.;Kuenzel, H. E.;Holsboer, F.
通讯作者：
Holsboer, F.
影响因子：
17.7
作者：
Bogdan, Ryan;Williamson, Douglas E.;Hariri, Ahmad R.
通讯作者：
Hariri, Ahmad R.
影响因子：
3.7
作者：
Alexander, Nina;Kuepper, Yvonne;Hennig, Juergen
通讯作者：
Hennig, Juergen