Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults.
Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults.
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DOI：
10.1038/npp.2010.159
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发表时间：
2010-12
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--
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外周细胞因子和其他促炎标志物的产生增加与精神疾病如重度抑郁症和创伤后应激障碍（PTSD）有关。最近的研究指出，早期生活压力，特别是儿童期虐待，是成年期全身炎症的独立和可预防的风险因素。一些数据表明，有童年虐待史的成年人对急性应激挑战表现出更高的炎症反应。为了进一步阐明儿童期虐待与促炎细胞因子产生之间的关系，我们检测了69名无抑郁症或PTSD的健康成人受试者的血浆IL-6对特里尔社会应激试验（TSST）的反应。在标准化的心理社会应激过程中，在n=19例中重度儿童期虐待（MAL）受试者和n=50例无虐待（CTL）对照者中测量系列血浆IL-6浓度，如儿童期创伤问卷（CTQ）的自我评定所示。CTQ总评分与IL-6应答的总体变化以及TSST期间的最大IL-6浓度呈正相关。相对于CTL组，MAL组观察到更大的急性IL-6释放和更高的IL-6浓度。炎症可能是一个重要的发育介导者，将生命早期的不良经历与成年后的不良身心健康联系起来。这项初步研究的结果需要在更大的样本中进行进一步的调查。
Increased production of peripheral cytokines and other pro-inflammatory markers has been linked to psychiatric disorders such as major depressive disorder and posttraumatic stress disorder (PTSD). Recent research has pointed to early life stress, particularly childhood maltreatment, as an independent and preventable risk factor for systemic inflammation in adulthood. Some data suggest that adults with a history of childhood maltreatment exhibit a heightened inflammatory response to acute stress challenge. To further elucidate the relationship between childhood maltreatment and pro-inflammatory cytokine production, we examined plasma IL-6 response to the Trier Social Stress Test (TSST) in 69 healthy adult subjects without depression or PTSD. Serial plasma IL-6 concentrations were measured during a standardized psychosocial stressor in n=19 subjects with moderate-severe childhood maltreatment (MAL) and n=50 controls without maltreatment (CTL), as indicated by self-ratings on the Childhood Trauma Questionnaire (CTQ). CTQ total scores were positively correlated with change in overall change in IL-6 response, as well as the maximum IL-6 concentration during the TSST. Greater acute IL-6 release and higher IL-6 concentrations over time were observed for the MAL group relative to the CTL group. Inflammation may be an important developmental mediator linking adverse experiences in early life to poor adult physical and mental health. The results of this preliminary study warrant further investigation in a larger sample.
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