Genomic imprinting in mammals: emerging themes and established theories.
Genomic imprinting in mammals: emerging themes and established theories.
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DOI：
10.1371/journal.pgen.0020147
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发表时间：
2006-11-24
期刊：
影响因子：
4.5
通讯作者：
Oakey RJ
中科院分区：
文献类型：
--
作者：
Wood AJ;Oakey RJ
在哺乳动物胚胎发育过程中发生的表观遗传事件对于正确的基因表达和细胞谱系的确定是必不可少的。由于配子体形成过程中建立的差异表观遗传标记，印迹基因仅从一个亲本等位基因表达。人们提出了几种理论来解释基因组印记在哺乳动物进化过程中所起的作用，但目前尚不清楚是否有一个单一的假设可以完全解释印记基因所起的多种作用。在这篇综述中，我们讨论了在小鼠基因组中定义印迹程度的努力，并提出不同的印迹位点可能是由不同的进化力量造成的。我们关注一组小的印迹结构域，它们由嵌入在多外显子转录本内含子中的父系表达基因组成，讨论这些位点上印迹的进化。
The epigenetic events that occur during the development of the mammalian embryo are essential for correct gene expression and cell-lineage determination. Imprinted genes are expressed from only one parental allele due to differential epigenetic marks that are established during gametogenesis. Several theories have been proposed to explain the role that genomic imprinting has played over the course of mammalian evolution, but at present it is not clear if a single hypothesis can fully account for the diversity of roles that imprinted genes play. In this review, we discuss efforts to define the extent of imprinting in the mouse genome, and suggest that different imprinted loci may have been wrought by distinct evolutionary forces. We focus on a group of small imprinted domains, which consist of paternally expressed genes embedded within introns of multiexonic transcripts, to discuss the evolution of imprinting at these loci.
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