Ophthalmic Artery Morphological and Hemodynamic Features in Acute Coronary Syndrome.
Ophthalmic Artery Morphological and Hemodynamic Features in Acute Coronary Syndrome.
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急性冠状动脉综合征的眼动脉形态和血流动力学特征
DOI：
10.1167/iovs.62.14.7
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发表时间：
2021-11-01
影响因子：
4.4
通讯作者：
Wang YL
中科院分区：
文献类型：
--
作者：
Wu LT;Wang JL;Wang YL
目的 检查急性冠脉综合征（ACS）患者眼动脉（OA）的形态和血流动力学变化。方法 这项横断面观察性研究包括 31 名 ACS 患者和 10 名健康对照 (HC)。 ACS 亚组包括 ST 段抬高型心肌梗死 (STEMI；n = 10)、非 STEMI (n = 10) 和不稳定型心绞痛 (n = 11)。基于计算机断层扫描血管造影重建 OA 三维 (3D) 模型，并定量测量 OA 的形态学方面。此外，通过计算流体动力学进行数值模拟来获得OA的血流动力学信息。结果该研究重建了 41 个 OA 模型。血流动力学模拟显示，与 HC 患者相比，ACS 患者的 OA 血流速度显着降低（中位速度，0.046 vs. 0.147 m/s；P < 0.001）。未观察到 OA 的形态数据存在差异。此外，未发现 OA 与同侧颈内动脉的质量流量比存在差异。 ACS 亚组和 HC 之间也观察到类似的差异。 OA血流速度与体重指数、腹围、左心室射血分数和三酰甘油呈负相关，与早期至晚期二尖瓣血流速度、N端脑钠肽前体、血清肌酐和钾呈正相关。结论 ACS 患者初始 OA 血流速度较慢，且与 ACS 相关临床参数相关。据我们所知，这是第一个利用3D模型重建和血流动力学模拟来分析ACS中OA特征的研究，为缺血性心脏病与眼部表现之间的关系提供了新的视角。
Purpose To examine the morphological and hemodynamic changes of the ophthalmic artery (OA) in patients with acute coronary syndrome (ACS). Methods This cross-sectional observational study included 31 patients with ACS and 10 healthy controls (HCs). The ACS subgroups were ST-segment elevation myocardial infarction (STEMI; n = 10), non-STEMI (n = 10), and unstable angina (n = 11). OA three-dimensional (3D) models were reconstructed based on computed tomographic angiography, and morphological aspects of the OA were measured quantitatively. Moreover, numerical simulation by computational fluid dynamics was used to obtain hemodynamic information of the OA. Results The study reconstructed 41 OA models. Hemodynamic simulation revealed a significant decrease in OA blood velocity in patients with ACS compared with the HCs (median velocity, 0.046 vs. 0.147 m/s; P < 0.001). No differences in the morphological data for the OA were observed. Also, no differences in the mass flow ratio of OA to the ipsilateral internal carotid artery was found. Similar differences were observed between the ACS subgroups and HCs. OA blood velocity was negatively correlated with body mass index, abdominal circumference, left ventricular ejection fraction, and triacylglycerol and was positively correlated with early to late transmitral flow velocity, N-terminal pro-brain natriuretic peptide, serum creatinine, and potassium. Conclusions The initial OA blood velocity was slower in patients with ACS and was associated with ACS-related clinical parameters. To our knowledge, this is the first study to analyze OA characteristics in ACS using 3D model reconstruction and hemodynamic simulation, providing new perspectives on the relationship between ischemic heart disease and ocular manifestations.
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影响因子：
3.7
作者：
Hu L;Huang X;You C;Li J;Hong K;Li P;Wu Y;Wu Q;Wang Z;Gao R;Bao H;Cheng X
通讯作者：
Cheng X
影响因子：
39.3
作者：
Linssen, Gerard C. M.;Bakker, Stephan J. L.;de Zeeuw, Dick
通讯作者：
de Zeeuw, Dick
影响因子：
4.1
作者：
Chang, Yuh-Shin;Chu, Chin-Chen;Jan, Ren-Long
通讯作者：
Jan, Ren-Long
影响因子：
8.3
作者：
Haffner, SM;D'Agostino, R;Saad, MF
通讯作者：
Saad, MF
影响因子：
--
作者：
Febina J;Sikkandar MY;Sudharsan NM
通讯作者：
Sudharsan NM