The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human.
The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human.
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DOI：
10.3390/microorganisms6030078
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发表时间：
2018-08-02
期刊：
影响因子：
4.5
通讯作者：
Corfield AP
中科院分区：
文献类型：
--
作者：
Corfield AP
糖蛋白是胃肠道和其他粘膜表面粘液保护屏障的主要参与者。特别是粘液糖蛋白或粘蛋白负责保护性凝胶屏障。它们的特点是碳水化合物含量高，存在于数量可变的串联重复结构域中。在整个进化过程中，粘蛋白一直作为粘膜屏障的组成部分，强调了它们的重要生物学地位。粘蛋白的糖基化是通过一系列生物合成途径过程实现的，这些过程产生了这些分子中发现的各种聚糖。因此，粘蛋白被具有糖码形式的信息的分子修饰。肠道微生物群以多种方式与粘膜粘液屏障相互作用，以完成其许多正常过程。综述中概述了细菌如何读取糖码并与正常和病理过程联系起来。
Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for the protective gel barrier. They are characterized by their high carbohydrate content, present in their variable number, tandem repeat domains. Throughout evolution the mucins have been maintained as integral components of the mucosal barrier, emphasizing their essential biological status. The glycosylation of the mucins is achieved through a series of biosynthetic pathways processes, which generate the wide range of glycans found in these molecules. Thus mucins are decorated with molecules having information in the form of a glycocode. The enteric microbiota interacts with the mucosal mucus barrier in a variety of ways in order to fulfill its many normal processes. How bacteria read the glycocode and link to normal and pathological processes is outlined in the review.
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