Penetrating eye injuries: a histopathological review.
Penetrating eye injuries: a histopathological review.
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穿透性眼损伤：组织病理学检查。
DOI：
10.1136/bjo.64.11.809
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Ryan,SJ
中科院分区：
文献类型：
--
作者：
Winthrop,SR;Cleary,PE;Minckler,DS;Ryan,SJ
本研究报告了严重穿透伤后人眼的组织学发现。这一发现证实了严重穿透伤眼视网膜脱离的发生率很高。在接受检查的34只眼睛中，有32只眼睛的视网膜被分离，其中27只眼睛有视网膜牵引力的证据。这些眼睛的组织学特征是眼内细胞增殖，产生睫状体膜、视网膜前膜和视网膜后膜。眼内细胞增殖在损伤后1周内可见或形成，通常在6周左右形成睫状膜。视网膜脱离者伤后1~2周可见视网膜前膜和视网膜后膜。结果表明，晶状体损伤、晶状体材料与玻璃体混合、玻璃体出血是促进玻璃体内成纤维细胞增殖的因素。玻璃体手术通过去除刺激和玻璃体支架以促进玻璃体内成纤维细胞的增殖，可能是治疗这些严重损伤眼的合理方法。从这个系列可以看出，玻璃体切除手术不应推迟到损伤后的第二周，到那时，大量的细胞植入可能已经开始。
This study reports the histological findings in human eyes after severe penetrating trauma. The findings confirm the high incidence of retinal detachment in eyes with severe penetrating injuries. The retina was detached in 32 out of the 34 eyes examined, with 27 having evidence of traction on the retina. These eyes were characterized histologically by intraocular cellular proliferation producing cyclitic, epiretinal, and retroretinal membranes. Intraocular cellular proliferation was discernible or established within 1 week of injury and typically resulted in a cyclitic membrane at about 6 weeks. Epiretinal and retroretinal membranes were found between 1 and 2 weeks after injury in eyes with a detached retina. The results indicate that a damaged lens, the admixture of lens material and vitreous, and the presence of vitreous haemorrhage were all factors promoting intravitreal fibroblastic proliferation. Vitreous surgery may be a rational method of treatment for these severely injured eyes by removing the stimulus and vitreous scaffold for intravitreal fibroblastic proliferation. From this series it would appear that vitrectomy should not be delayed beyond the second week of injury, by which time massive cellular ingrowth may already be under way.
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