Classically conditioned modulation of pain depends on stimulus intensity.
Classically conditioned modulation of pain depends on stimulus intensity.
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DOI：
10.1007/s00221-021-06285-4
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发表时间：
2022-04
影响因子：
2
通讯作者：
Coppieters, Michel W.
中科院分区：
文献类型：
--
作者：
Harvie, Daniel S.;Poolman, Eva Y.;Madden, Victoria J.;Olthof, Nick A.;Coppieters, Michel W.
关键词：
与疼痛相关的无伤大雅的线索会增强疼痛感。这被称为经典条件性痛觉过敏。这种效应的大小在不同的条件下是不同的。我们的目的是测试疼痛相关线索的致敏效应是否取决于配对测试刺激的强度。为了做到这一点，两个虚拟现实环境以一种平衡的方式与疼痛或非疼痛的振动触觉刺激配对。两种环境的差异效应是用三个不同强度水平的配对皮肤电试验刺激的疼痛强度评级来评估的。40名健康参与者参与了这项研究；30名参与者在学习阶段经历了足够的痛苦，并被纳入主要分析。环境的影响（p = 0.014）和环境与测试刺激强度的交互作用（p = 0.046）。只有最强烈的测试刺激受到环境的调节。虽然影响很小，但结果与疼痛相关的线索可能在一定程度上在某些条件下引起痛觉过敏的命题一致。特别是，结果强调了在最初的痛苦经历期间和之后刺激强度的潜在相关性。需要进一步注意全面了解影响经典条件痛觉过敏的变量。在线版本包含补充材料，可在10.1007/s00221-021-06285-4获得。
Innocuous cues that become associated with pain can enhance pain. This is termed classically conditioned hyperalgesia. The size of this effect varies under different conditions. We aimed to test whether the sensitising effect of pain-associated cues depends on the intensity of the paired test stimulus. To do this, two virtual reality environments were paired with either painful or non-painful vibrotactile stimuli in a counterbalanced fashion. The differential effect of the two environments was evaluated using pain intensity ratings of paired electrocutaneous test stimuli at three different intensity levels. Forty healthy participants were included in the study; 30 participants experienced sufficient pain during the learning phase and were included in the main analysis. An effect of environment (p = 0.014) and interaction between environment and test stimulus intensity was found (p = 0.046). Only the most intense test stimulus was modulated by environment. While the effect was small, the results are consistent with the proposition that pain-associated cues may induce hyperalgesia to some degree, under certain conditions. In particular, results highlight the potential relevance of stimulus intensity during and after the initial painful experience. Further attention is needed to comprehensively understand the variables that impact classically conditioned hyperalgesia. The online version contains supplementary material available at 10.1007/s00221-021-06285-4.
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