The killer's kiss: the many functions of NK cell immunological synapses.

The killer's kiss: the many functions of NK cell immunological synapses.
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DOI:
10.1016/j.ceb.2008.05.006
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发表时间:
2008-10
影响因子:
7.5
通讯作者:
Strominger JL
Strominger JL
中科院分区:
生物学2区
文献类型:
--
作者:
Krzewski K;Strominger JL

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自然杀伤(NK)细胞由参与保护免受微生物病原体和肿瘤侵害的淋巴细胞亚群组成。NK细胞识别缺失MHC I类分子的宿主细胞,并通过溶解颗粒的局部递送来消除它们。大多数NK细胞效应子功能需要直接的细胞与细胞接触。与靶细胞的结合伴随着在细胞-细胞界面处产生称为免疫突触的复杂结构。最近的研究极大地促进了表征几种类型的NK细胞免疫突触和理解起源于这个有趣的地方的各种过程。新出现的图片说明NK细胞免疫突触作为高度复杂的NK细胞活性调节的位点。
Natural Killer (NK) cells comprise a subset of lymphocytes involved in protection against microbial pathogens and tumors. NK cells recognize host cells that are missing MHC class I molecules and eliminate them through localized delivery of lytic granules. The majority of NK cell effector functions require direct cell to cell contact. Binding to a target cell is accompanied by creation of complex structures at the cell-cell interface known as immunological synapses. Recent studies have contributed immensely to characterization several types of NK cell immunological synapse and understanding of the variety of processes originating at this intriguing place. The emerging picture illustrates NK cell immune synapses as the sites of highly complex regulation of NK cell activity.
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