Layer-specific modulation of pyramidal cell excitability by electroconvulsive shock
Layer-specific modulation of pyramidal cell excitability by electroconvulsive shock
复制标题
电休克对锥体细胞兴奋性的层特异性调节
DOI：
10.1016/j.neulet.2019.134383
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发表时间：
2019
影响因子：
2.5
通讯作者：
Kato Nobuo
中科院分区：
文献类型：
--
作者：
Ueta Yoshifumi;Yamamoto Ryo;Kato Nobuo
皮质兴奋性的失调与神经退行性疾病和神经精神疾病的行为和认知缺陷密切相关。电休克（ECS）改变神经元的兴奋性，并已被用于治疗抑郁症和心境障碍。然而，ECS在皮层回路中的作用和靶点仍然知之甚少。在这里，我们表明，ECS不同地改变内在特性的锥体细胞（PC）之间的浅层和深层。在第2/3层PC中，ECS引起膜超极化和输入电阻的降低。在第5层PC中，ECS也诱导膜超极化，但对输入电阻影响不大。在第6层PC中，ECS对静息膜电位和输入电阻均无影响。此外，ECS降低了第2/3层中的PC的放电频率，但在第5层和第6层中没有降低。我们进一步研究了ECS诱导的Ca 2+电流内流的变化，并观察到增强的Ca 2+电流在PC的2/3和5层，但不是第6层。因此，这项研究表明，层特异性抑制PC兴奋性，这将是ECS作用于皮层活动的机制的基础。
Dysregulation of cortical excitability crucially involves in behavioral and cognitive deficits of neurodegenerative and neuropsychiatric diseases. Electroconvulsive shock (ECS) changes neuronal excitability and has been used in the therapy of major depressive disorder and mood disorders. However, the action and the targets of the ECS in the cortical circuits are still poorly understood. Here we show that the ECS differently changes intrinsic properties of pyramidal cells (PCs) among superficial and deep layers. In layer 2/3 PCs, the ECS induced membrane hyperpolarization and the reduction of input resistances. In layer 5 PCs, the ECS also induced membrane hyperpolarization but had little effects on input resistances. In layer 6 PCs, the ECS had no effects on both of resting membrane potentials and input resistances. In addition, the ECS reduced the firing frequency of PCs in layer 2/3 but not in both layers 5 and 6. We further examined the ECS-induced changes in the influx of Ca2+currents, and observed an enhanced Ca2+currents in PCs of both layers 2/3 and 5 but not of layer 6. Thus, this study suggests the layer-specific suppression of PC excitability which will underlie the mechanism of the ECS action on the cortical activity.
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影响因子：
2.5
作者：
Hattox, Alexis M.;Nelson, Sacha B.
通讯作者：
Nelson, Sacha B.
影响因子：
3.4
作者：
Y. Sakagami;Kenji Yamamoto;S. Sugiura;K. Inokuchi;Takuji Hayashi;N. Kato
通讯作者：
Y. Sakagami;Kenji Yamamoto;S. Sugiura;K. Inokuchi;Takuji Hayashi;N. Kato
DOI：
10.1523/jneurosci.4023-14.2015
发表时间：
2015-02
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
N. Yamawaki;G. Shepherd
通讯作者：
N. Yamawaki;G. Shepherd
影响因子：
64.8
作者：
Yizhar, Ofer;Fenno, Lief E.;Prigge, Matthias;Schneider, Franziska;Davidson, Thomas J.;O'Shea, Daniel J.;Sohal, Vikaas S.;Goshen, Inbal;Finkelstein, Joel;Paz, Jeanne T.;Stehfest, Katja;Fudim, Roman;Ramakrishnan, Charu;Huguenard, John R.;Hegemann, Peter;Deisseroth, Karl
通讯作者：
Deisseroth, Karl
DOI：
10.1523/jneurosci.6752-10.2011
发表时间：
2011-08
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Kenji Yamamoto;Y. Ueta;Li Wang;R. Yamamoto;N. Inoue;K. Inokuchi;A. Aiba;H. Yonekura;N. Kato
通讯作者：
Kenji Yamamoto;Y. Ueta;Li Wang;R. Yamamoto;N. Inoue;K. Inokuchi;A. Aiba;H. Yonekura;N. Kato