A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs.
A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs.
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DOI：
10.3390/ijms22179535
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发表时间：
2021-09-02
影响因子：
5.6
通讯作者：
Wei Y
中科院分区：
文献类型：
--
作者：
Xie Y;Wei Y
长链非编码RNA（lncRNA）在宿主先天免疫系统中的抗微生物反应中代表关键的转录和转录后基因调节因子。研究表明，lncRNA以高度组织和细胞特异性的方式表达，并通过多种分子机制参与先天免疫细胞的分化和功能，以及炎症和抗病毒过程。这些lncRNA通过与DNA、RNA或蛋白质以顺式或反式模式相互作用来发挥功能，依赖于它们的特定序列或它们的转录和加工。lncRNA功能失调与多种人类非感染性疾病相关，例如炎症性肠病、心血管疾病和糖尿病。在这里，我们提供了一个概述的调控和机制的lncRNA功能的先天免疫细胞的发育和分化，并在激活或抑制先天免疫反应。这些阐明可能有利于针对炎症和先天免疫介导的疾病的治疗策略的发展。
Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific- manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases.
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影响因子：
2.6
作者：
Beirão BC;Raposo T;Pang LY;Argyle DJ
通讯作者：
Argyle DJ
影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
影响因子：
64.5
作者：
Cawley, S;Bekiranov, S;Gingeras, TR
通讯作者：
Gingeras, TR
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA