Role of the hypothalamus in mediating protective effects of dietary restriction during aging.
Role of the hypothalamus in mediating protective effects of dietary restriction during aging.
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DOI：
10.1016/j.yfrne.2012.12.001
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发表时间：
2013-04
影响因子：
7.4
通讯作者：
Mobbs, Charles V.
中科院分区：
文献类型：
--
作者：
Dacks, Penny A.;Moreno, Cesar L.;Kim, Esther S.;Marcellino, Bridget K.;Mobbs, Charles V.
关键词：
饮食限制（DR）可以延长许多动物和酵母的寿命并减轻疾病负担，但尽管进行了广泛的研究，但介导这些显著保护作用的机制仍有待阐明。尽管人们普遍认为DR的保护作用是细胞自主的，但有大量证据表明，包括DR在内的许多全身对营养状态的反应是由营养感应神经元调节的。在这篇综述中，我们探讨了下丘脑腹内侧的营养感知神经元分层调节饮食限制的保护反应的假设。我们描述了由下丘脑分层调节的多种外周反应，并从多种模型（包括无脊椎动物、哺乳动物细胞培养和啮齿动物研究）中收集了饮食限制的非细胞自主信号的证据。
Dietary restriction (DR) can extend lifespan and reduce disease burden across a wide range of animals and yeast but the mechanisms mediating these remarkably protective effects remain to be elucidated despite extensive efforts. Although it has generally been assumed that protective effects of DR are cell-autonomous, there is considerable evidence that many whole-body responses to nutritional state, including DR, are regulated by nutrient-sensing neurons. In this review, we explore the hypothesis that nutrient sensing neurons in the ventromedial hypothalamus hierarchically regulate the protective responses of dietary restriction. We describe multiple peripheral responses that are hierarchically regulated by the hypothalamus and we present evidence for non-cell autonomous signaling of dietary restriction gathered from a diverse range of models including invertebrates, mammalian cell culture, and rodent studies.
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影响因子：
29
作者：
Blouet, Clemence;Ono, Hiraku;Schwartz, Gary J.
通讯作者：
Schwartz, Gary J.
DOI：
10.1073/pnas.0405775102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Broughton, SJ;Piper, MDW;Partridge, L
通讯作者：
Partridge, L
影响因子：
4.3
作者：
Anisimov, Vladimir N.;Zabezhinski, Mark A.;Blagosklonny, Mikhail V.
通讯作者：
Blagosklonny, Mikhail V.
影响因子：
64.8
作者：
Bishop, Nicholas A.;Guarente, Leonard
通讯作者：
Guarente, Leonard
影响因子：
8.2
作者：
Baker, D;Evans, M;Sherwin, R
通讯作者：
Sherwin, R