Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats.
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats.
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DOI：
10.1007/s00213-022-06174-w
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发表时间：
2022-09
影响因子：
3.4
通讯作者：
Groman, Stephanie M.
中科院分区：
文献类型：
--
作者：
Villiamma, Peroushini;Casby, Jordan;Groman, Stephanie M.
在青春期发生在大脑中的解剖，结构和功能适应被认为有助于改善在这个发展阶段发生的决策功能。这些神经适应的机制尚不清楚，但发展轨迹的偏差被认为是导致精神疾病（包括成瘾）出现的原因。然而，支持这一假设的直接证据有限。在这里，我们使用了最近开发的反向学习协议来调查青少年决策轨迹和成年后可卡因服用行为之间的预测关系。在整个青春期和成年期的男性和女性Long-Evans大鼠的逆向学习任务的决策功能进行了评估。将逐个试验的选择数据与学习模型拟合，以量化个体大鼠的选择行为受到奖励（例如， 参数）和未奖励（例如， 参数）的结果。我们报告说，反向学习的表现在青春期有所改善，这是由于奖励结果的价值更新增加（例如， 参数）。此外，参数的变化率预测了参数的个体差异，特别是成年后的可卡因服用行为：发现青春期轨迹较浅的大鼠成年后的参数较低，可卡因自我给药较多。这些数据表明，青少年发育在药物使用敏感性方面起着关键作用。未来的研究旨在了解这些与年龄相关的决策变化背后的神经生物学机制，可以为介导成瘾易感性的生物行为机制提供新的见解。
The anatomical, structural, and functional adaptations that occur in the brain during adolescence are thought to facilitate improvements in decision-making functions that are known to occur during this stage of development. The mechanisms that underlie these neural adaptations are not known, but deviations in developmental trajectories have been proposed to contribute to the emergence of mental illness, including addiction. Direct evidence supporting this hypothesis, however, has been limited. Here, we used a recently developed reversal-learning protocol to investigate the predictive relationship between adolescent decision-making trajectories and cocaine-taking behaviors in adulthood. Decision-making functions in the reversal-learning task were assessed throughout adolescence and into adulthood in male and female Long–Evans rats. Trial-by-trial choice data was fitted with a reinforcement-learning model to quantify the degree to which choice behavior of individual rats was influenced by rewarded (e.g., parameter) and unrewarded (e.g., parameter) outcomes. We report that reversal-learning performance improved during adolescence and that this was due to an increase in value updating for rewarded outcomes (e.g., parameter). Furthermore, the rate of change in the parameter predicted individual differences in the parameter and, notably, cocaine-taking behaviors in adulthood: Rats that had a shallower adolescent trajectory were found to have a lower parameter and greater cocaine self-administration in adulthood. These data indicate that adolescent development plays a critical role in drug use susceptibility. Future studies aimed at understanding the neurobiological mechanisms that underlie these age-related changes in decision-making could provide new insights into the biobehavioral mechanisms mediating addiction susceptibility.
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影响因子：
10.6
作者：
Groman, Stephanie M.;Massi, Bart;Taylor, Jane R.
通讯作者：
Taylor, Jane R.
额度额：从童年到成年期的扩散张量成像表征和发育变化。
影响因子：
4.8
作者：
Karlsgodt KH;John M;Ikuta T;Rigoard P;Peters BD;Derosse P;Malhotra AK;Szeszko PR
通讯作者：
Szeszko PR
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.5
作者：
Ballinger, GA
通讯作者：
Ballinger, GA
影响因子：
16.2
作者：
Groman, Stephanie M.;Keistler, Colby;Taylor, Jane R.
通讯作者：
Taylor, Jane R.