Interneuronal mechanism for Tinbergen's hierarchical model of behavioral choice.
Interneuronal mechanism for Tinbergen's hierarchical model of behavioral choice.
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DOI：
10.1016/j.cub.2014.07.044
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发表时间：
2014-09-08
期刊：
影响因子：
9.2
通讯作者：
Kemenes, Ildiko
中科院分区：
文献类型：
--
作者：
Pirger, Zsolt;Crossley, Michael;Laszlo, Zita;Naskar, Souvik;Kemenes, Gyoergy;O'Shea, Michael;Benjamin, Paul R.;Kemenes, Ildiko
最近的行为选择研究支持这样一种观点，即决定执行一种行为而不是另一种行为取决于共享的神经元间网络的重新配置。我们研究了另一种决策策略，来自经典的行为学文献，提出行为选择取决于自治网络之间的竞争。根据这个模型，行为选择取决于不相容的等级组织行为之间的抑制性相互作用。我们提供的证据，这通过调查介导的行为选择两个自主电路的基础全身撤回和喂养的池塘蜗牛的神经元间的机制。全身退缩是一种防御性反射，由与捕食者的触觉接触引发。正如层次模型所预测的那样，引起全身退缩反应的触觉刺激也会抑制在进食刺激存在下的持续进食。通过记录来自进食和戒断网络的神经元，我们发现产生这两种行为的神经元间元件和运动神经元元件之间没有直接的突触连接。相反，我们发现，行为选择取决于两种独特类型的中间神经元之间的相互作用，它们具有不对称的突触连接，允许撤回以取代进食。一种类型的中间神经元，胸膜颊（PlB），是一个外在的调节神经元的喂养网络，完全抑制喂养时，从第二种类型的中间神经元，足背12（Ped12）的触摸诱导的单突触输入兴奋。PeD12通过提供连接两个行为网络的突触通路在行为选择中起着关键作用，这两个行为网络是全身退缩对进食的竞争优势的基础。相互排斥的行为之间的行为选择是分层组织的触摸引起的全身退缩抑制蔗糖驱动的进食节律两个中间神经元具有不对称的连接允许退缩超越进食抑制进食是由于增强了紧张性抑制目前的行为选择模型依赖于共享的中间神经元网络的重新配置。Pirger等人提供证据的替代丁伯根模型，这取决于一个层次为基础的竞争自治网络之间。非对称抑制性神经元间通路允许一种行为支配另一种行为。
Recent studies of behavioral choice support the notion that the decision to carry out one behavior rather than another depends on the reconfiguration of shared interneuronal networks. We investigated another decision-making strategy, derived from the classical ethological literature, which proposes that behavioral choice depends on competition between autonomous networks. According to this model, behavioral choice depends on inhibitory interactions between incompatible hierarchically organized behaviors. We provide evidence for this by investigating the interneuronal mechanisms mediating behavioral choice between two autonomous circuits that underlie whole-body withdrawal and feeding in the pond snail Lymnaea. Whole-body withdrawal is a defensive reflex that is initiated by tactile contact with predators. As predicted by the hierarchical model, tactile stimuli that evoke whole-body withdrawal responses also inhibit ongoing feeding in the presence of feeding stimuli. By recording neurons from the feeding and withdrawal networks, we found no direct synaptic connections between the interneuronal and motoneuronal elements that generate the two behaviors. Instead, we discovered that behavioral choice depends on the interaction between two unique types of interneurons with asymmetrical synaptic connectivity that allows withdrawal to override feeding. One type of interneuron, the Pleuro-Buccal (PlB), is an extrinsic modulatory neuron of the feeding network that completely inhibits feeding when excited by touch-induced monosynaptic input from the second type of interneuron, Pedal-Dorsal12 (PeD12). PeD12 plays a critical role in behavioral choice by providing a synaptic pathway joining the two behavioral networks that underlies the competitive dominance of whole-body withdrawal over feeding. Behavioral choice between mutually exclusive behaviors is hierarchically organized Touch-induced whole-body withdrawal inhibits sucrose-driven feeding rhythms Two interneurons with asymmetrical connectivity allow withdrawal to override feeding Suppression of feeding is due to the enhancement of tonic inhibition A current model of behavioral choice depends on the reconfiguration of shared interneuronal networks. Pirger et al. provide evidence for the alternative Tinbergen model, which depends on a hierarchically based competition between autonomous networks. An asymmetrical inhibitory interneuronal pathway allows one behavior to dominate the other.
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