Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue.
Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue.
复制标题
DOI：
10.1038/s41467-021-23770-0
复制
发表时间：
2021-06-09
影响因子：
16.6
通讯作者：
Eckel-Mahan KL
中科院分区：
文献类型：
--
作者：
Ribas-Latre A;Santos RB;Fekry B;Tamim YM;Shivshankar S;Mohamed AMT;Baumgartner C;Kwok C;Gebhardt C;Rivera A;Gao Z;Sun K;Heiker JT;Snyder BE;Kolonin MG;Eckel-Mahan KL
白色脂肪组织(WAT)的增生性扩张在一定程度上依赖于WAT间质血管细胞部分(SVF)中脂肪细胞前体细胞的增殖。这项研究揭示了体内内脏和皮下脂肪的SVF在昼夜节律和摄食诱导下的细胞增殖模式，瘦小鼠摄食后内脏脂肪细胞前体细胞的增殖速度更快。禁食或失去节律性摄食可以消除这种昼夜增殖，而高脂肪摄食或分子生物钟的遗传干扰会改变增殖基因的时间表达，并影响eWAT中SVF的昼夜增殖。令人惊讶的是，高脂饮食逆转足以逆转eWAT中升高的SVF增殖，但不足以恢复SVF增殖的日常模式，这表明高脂饮食导致脂肪昼夜节律的持续扰乱。总而言之，生物钟和摄食同时给予脂肪细胞前体细胞增殖的动态、调控控制，这可能是随着时间的推移脂肪组织扩张和健康的关键决定因素。在脂肪组织的扩张过程中，脂肪细胞前体细胞增殖并经历成脂过程。在这里，作者表明，内脏脂肪组织中的脂肪细胞前体细胞的增殖具有昼夜模式，这取决于能量摄入量和生物钟。
Hyperplastic expansion of white adipose tissue (WAT) relies in part on the proliferation of adipocyte precursor cells residing in the stromal vascular cell fraction (SVF) of WAT. This study reveals a circadian clock- and feeding-induced diurnal pattern of cell proliferation in the SVF of visceral and subcutaneous WAT in vivo, with higher proliferation of visceral adipocyte progenitor cells subsequent to feeding in lean mice. Fasting or loss of rhythmic feeding eliminates this diurnal proliferation, while high fat feeding or genetic disruption of the molecular circadian clock modifies the temporal expression of proliferation genes and impinges on diurnal SVF proliferation in eWAT. Surprisingly, high fat diet reversal, sufficient to reverse elevated SVF proliferation in eWAT, was insufficient in restoring diurnal patterns of SVF proliferation, suggesting that high fat diet induces a sustained disruption of the adipose circadian clock. In conclusion, the circadian clock and feeding simultaneously impart dynamic, regulatory control of adipocyte progenitor proliferation, which may be a critical determinant of adipose tissue expansion and health over time. During the expansion of adipose tissue adipocyte progenitor cells proliferate and undergo adipogenesis. Here, the authors show that adipocyte progenitor cell proliferation in visceral adipose tissue has a diurnal pattern, which is dependent on both energy intake and the circadian clock.
登录
查看更多内容
人脂肪外植体中时钟基因的昼夜节律。
影响因子：
6.9
作者：
Gomez-Santos, Cecilia;Gomez-Abellan, Purificacion;Madrid, Juan A.;Hernandez-Morante, Juan J.;Lujan, Juan A.;Ordovas, Jose M.;Garaulet, Marta
通讯作者：
Garaulet, Marta
昼夜主义代谢的地图集揭示了时钟之间全系统的协调和通信。
影响因子：
64.5
作者：
Dyar KA;Lutter D;Artati A;Ceglia NJ;Liu Y;Armenta D;Jastroch M;Schneider S;de Mateo S;Cervantes M;Abbondante S;Tognini P;Orozco-Solis R;Kinouchi K;Wang C;Swerdloff R;Nadeef S;Masri S;Magistretti P;Orlando V;Borrelli E;Uhlenhaut NH;Baldi P;Adamski J;Tschöp MH;Eckel-Mahan K;Sassone-Corsi P
通讯作者：
Sassone-Corsi P
影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
Panda S
影响因子：
5.6
作者：
Achari AE;Jain SK
通讯作者：
Jain SK
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S