Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
复制标题
DOI：
10.1016/j.cmet.2018.08.004
复制
发表时间：
2019-02-05
期刊：
影响因子：
29
通讯作者：
Panda S
中科院分区：
文献类型：
--
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
生物钟突变小鼠对代谢性疾病的易感性增加，这导致了这样一种想法，即分子时钟对于代谢稳态是必要的。然而，这些小鼠往往缺乏正常的进食-禁食周期。我们测试了限时喂养是否可以在全身Cry1、Cry2以及肝脏特异的BMal1和Rev-erbα/β基因敲除小鼠中预防肥胖和代谢综合征。当提供自由进食时，这些小鼠的体重迅速增加，并表现出特定于基因的代谢缺陷。然而，当在TRF下喂食相同的食物时(黑暗阶段的食物获取限制为10小时)，它们可以免受过度体重增加和代谢性疾病的影响。转录组和代谢组分析表明，TRF减少了肝脏脂质的积累，并增强了细胞对代谢应激的防御。这些结果表明，生物钟通过维持每日摄食和禁食的节律，以及维持营养和细胞应激反应之间的平衡，来维持代谢平衡。Chaix等人。研究表明，限时喂食(TRF；在活动期获得10小时食物)可以改善生物钟受损小鼠的代谢健康。他们的结果指出，代谢功能障碍是行为节律紊乱(如进食-禁食)的继发性障碍，可以通过TRF纠正。
Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal feeding-fasting cycle. We tested whether time-restricted feeding (TRF) could prevent obesity and metabolic syndrome in whole body Cry1;Cry2 and in liver-specific Bmal1 and Rev-erbα/β knockout mice. When provided ad libitum access to food, these mice rapidly gained weight and showed genotype-specific metabolic defects. However, when fed the same diet under TRF (food access restricted to 10 hours during the dark phase) they were protected from excessive weight gain and metabolic diseases. Transcriptome and metabolome analyses showed that TRF reduced the accumulation of hepatic lipids and enhanced cellular defenses against metabolic stress. These results suggest that the circadian clock maintains metabolic homeostasis by sustaining daily rhythms in feeding and fasting, and by maintaining balance between nutrient and cellular stress responses. Chaix et al. show that time-restricted feeding (TRF; 10h access to food during the active phase) can improve metabolic health in mice with a compromised circadian clock. Their results point to metabolic dysfunction as secondary to disrupted behavioral rhythms (e.g. feeding-fasting), and which can be redressed by TRF.
登录
查看更多内容
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
DOI：
10.1126/science.1198125
发表时间：
2011-03-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Feng D;Liu T;Sun Z;Bugge A;Mullican SE;Alenghat T;Liu XS;Lazar MA
通讯作者：
Lazar MA
影响因子：
29
作者：
Adamovich Y;Rousso-Noori L;Zwighaft Z;Neufeld-Cohen A;Golik M;Kraut-Cohen J;Wang M;Han X;Asher G
通讯作者：
Asher G
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK
影响因子：
29
作者：
Chaix A;Zarrinpar A;Miu P;Panda S
通讯作者：
Panda S