Mechanisms and immunotherapies of HBV- and NAFLD-related hepatocellular carcinoma
Mechanisms and immunotherapies of HBV- and NAFLD-related hepatocellular carcinoma
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HBV 和 NAFLD 相关肝细胞癌的机制和免疫治疗
DOI：
10.20517/2394-5079.2020.05
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Chun-Hong Ma
中科院分区：
文献类型：
--
作者：
Xiao-Jia Song;Chun-Hong Ma
B型肝炎病毒（HBV）感染是世界范围内肝细胞癌（HCC）最重要的危险因素，非酒精性脂肪性肝病（NAFLD）已发展成为慢性肝病、肝硬化和HCC的主要病因。尽管核苷（酸）类似物被推荐为治疗慢性B型肝炎的一线药物，但HBV的不完全根除成为慢性B型肝炎甚至肝癌有效治愈的障碍。NAFLD是指一系列肝脏代谢紊乱，与多系统疾病有关。鉴于肝细胞的特异性和免疫细胞在肝脏中的富集，本文综述了HBV感染和脂质代谢异常诱导肝细胞直接致瘤和免疫细胞介导的间接致瘤机制。我们还讨论了HBV和NAFLD-HCC之间的免疫细胞的异同，最后集中在肝癌的临床前和临床研究的新的免疫治疗。
Hepatitis B virus (HBV) infection remains the most important risk factor for hepatocellular carcinoma (HCC) worldwide and nonalcoholic fatty liver disease (NAFLD) has developed as major etiology of chronic liver diseases, cirrhosis and eventually HCC in the last decades. Although nucleos(t)ide analogs are recommended as the first-line drug for patients with chronic hepatitis B, incomplete eradication of HBV serves as an obstacle for effective cure of chronic hepatitis B and even HCC. NAFLD refers to a spectrum of hepatic metabolic disorders, compromised with multi-system diseases. Considering the specificity of hepatocytes and enrichment of immune cells in liver, this review aims to summarize the mechanisms of direct pro-tumorigenesis to hepatocytes induced by HBV infection and abnormal lipid metabolism, and indirect oncogenic processes mediated by immune cells. We also discuss similarities and differences of immune cells between HBVand NAFLD-HCC and finally focus on the novel immunotherapies concerning preclinical and clinical studies for liver cancer.
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