Impaired iron status in aging research.

Impaired iron status in aging research.
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DOI:
10.3390/ijms13022368
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发表时间:
2012
影响因子:
5.6
通讯作者:
Leeuwenburgh C
Leeuwenburgh C
中科院分区:
生物学2区
文献类型:
--
作者:
Xu J;Jia Z;Knutson MD;Leeuwenburgh C

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衰老与铁代谢和储存的紊乱有关。在过去的十年中,利用培养细胞和动物模型在理解衰老和年龄相关疾病的细胞和分子机制方面取得了显着进展。该领域已经从描述性研究转向以铁螯合和去除为重点的潜在干预研究。然而,一些研究结果仍然存在争议且不一致。这篇综述总结了衰老研究中铁稳态失调的重要特征,特别强调了啮齿动物模型中与年龄相关的疾病机制的当前知识。
Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
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