Research informatics and the COVID-19 pandemic: Challenges, innovations, lessons learned, and recommendations.
Research informatics and the COVID-19 pandemic: Challenges, innovations, lessons learned, and recommendations.
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DOI：
10.1017/cts.2021.26
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发表时间：
2021-03-16
影响因子：
2.6
通讯作者：
Tsinoremas NF
中科院分区：
文献类型：
--
作者：
Bookman RJ;Cimino JJ;Harle CA;Kost RG;Mooney S;Pfaff E;Rojevsky S;Tobin JN;Wilcox A;Tsinoremas NF
美国国立卫生研究院临床和转化科学奖（CTSA）的获得者已经工作了十多年，以建立支持临床和转化研究的信息学基础设施。事实证明，这一基础设施通过对患者的直接护理、临床决策支持、对研究人员和从业人员的培训以及公共卫生监测和临床研究，为支持应对当前COVID-19大流行提供了宝贵的支持，如果没有CTSAs多年来的基础性工作，这些基础设施是无法实现的。在本文中，我们提供了我们对COVID-19工作的看法，并介绍了对CTSA站点的调查的相关结果，以扩大我们对其信息学计划的主要特征，他们在COVID-19下遇到的信息学相关挑战以及他们为应对大流行而开发的一些创新和解决方案的理解。回应表明，医疗保健提供者和研究人员越来越依赖获取电子健康记录（EHR）数据，以满足当地需求并与其他机构和国家联盟共享。ctsa在数据采集、标准、交换和共享政策方面的初步工作都为解决方案做出了贡献，最好的例证是在创纪录的时间内创建了国家COVID-19队列协作（N3C）的国家临床数据存储库。调查数据支持信息学和公共卫生投资以及进一步研究领域的七项建议，以支持后covid -19时代的临床和转化研究。
The recipients of NIH’s Clinical and Translational Science Awards (CTSA) have worked for over a decade to build informatics infrastructure in support of clinical and translational research. This infrastructure has proved invaluable for supporting responses to the current COVID-19 pandemic through direct patient care, clinical decision support, training researchers and practitioners, as well as public health surveillance and clinical research to levels that could not have been accomplished without the years of ground-laying work by the CTSAs. In this paper, we provide a perspective on our COVID-19 work and present relevant results of a survey of CTSA sites to broaden our understanding of the key features of their informatics programs, the informatics-related challenges they have experienced under COVID-19, and some of the innovations and solutions they developed in response to the pandemic. Responses demonstrated increased reliance by healthcare providers and researchers on access to electronic health record (EHR) data, both for local needs and for sharing with other institutions and national consortia. The initial work of the CTSAs on data capture, standards, interchange, and sharing policies all contributed to solutions, best illustrated by the creation, in record time, of a national clinical data repository in the National COVID-19 Cohort Collaborative (N3C). The survey data support seven recommendations for areas of informatics and public health investment and further study to support clinical and translational research in the post-COVID-19 era.
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