Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders.
Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders.
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奶牛血清肝因子：围产期变异和能量相关代谢紊乱的变化
DOI：
10.1186/s12917-018-1560-7
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发表时间：
2018-08-13
影响因子：
2.6
通讯作者：
Zhao B
中科院分区：
文献类型：
--
作者：
Wang J;Zhu X;She G;Kong Y;Guo Y;Wang Z;Liu G;Zhao B
奶牛在围产期极易发生脂肪肝、酮病等能量代谢紊乱。血管生成素样蛋白4（ANGPTL 4）和成纤维细胞生长因子21（FGF 21）被称为肝细胞因子，在脂质代谢中起重要作用。本研究旨在探讨围产期奶牛血清ANGPTL 4和FGF 21浓度的变化及其与泌乳早期奶牛能量代谢紊乱的关系。在本试验中，每周血液样品从4周前的预期产犊日期，通过4 wk后calved.Experiment II：血液参数测定健康奶牛（n= 30）和奶牛临床酮病（n= 29）和脂肪肝（n= 25）在第一个4 wk的泌乳期。结果血清ANGPTL 4和FGF 21浓度在分娩时达到峰值，在随后的2周内迅速下降，血清ANGPTL 4和FGF 21浓度与血清非酯化脂肪酸（NEFA）浓度呈正相关（r= 0.856，P = 003;r= 0.848，P = 0.004）。临床酮病和脂肪肝奶牛血清ANGPTL 4和FGF 21浓度显著高于健康奶牛（P< 0.01）。FGF 21和ANGPTL 4在奶牛能量代谢的适应过程中发挥重要作用，可能参与了围产期奶牛能量代谢紊乱的病理过程。
BackgroundDuring peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important roles in lipid metabolism. The purposes of our study were to evaluate variations of serum ANGPTL4 and FGF21 concentrations in periparturient dairy cows and changes in these serum analyte concentrations of energy-related metabolic disorders in early lactation dairy cows.This study was divided into two experiments.Experiment I:Blood parameters were measured in healthy periparturient Holstein cows from 4 wk antepartum to 4 wk postpartum (n= 219). In this experiment, weekly blood samples were obtained from 4 wk before the expected calving date through 4 wk after calving.Experiment II:Blood parameters were measured in healthy cows (n= 30) and cows with clinical ketosis (n= 29) and fatty liver (n= 25) within the first 4 wk of lactation. In the present study, all blood samples were collected from the coccygeal vein in the early morning before feeding.ResultsSerum ANGPTL4 and FGF21 concentrations peaked at parturition, and declined rapidly over the following 2 wk Serum ANGPTL4 and FGF21 concentrations were positively correlated with serum non-esterified fatty acids (NEFA) concentration (r= 0.856,P= 003;r= 0.848,P= 0.004, respectively). Cows with clinical ketosis and fatty liver had significantly higher serum ANGPTL4 and FGF21 concentrations than healthy cows (P< 0.01).ConclusionSerum ANGPTL4 and FGF21 concentrations were elevated during peripartum period, suggesting that energy balance changes that were associated with parturition contributed significantly to these effects. Although FGF21 and ANGPTL4 could play important roles in the adaptation of energy metabolism, they may be involved in the pathological processes of energy metabolism disorders of dairy cows in the peripartum period.
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DOI：
10.4137/grsb.s14116
发表时间：
2014
期刊：
Gene regulation and systems biology
影响因子：
--
作者：
Khan MJ;Jacometo CB;Graugnard DE;Corrêa MN;Schmitt E;Cardoso F;Loor JJ
通讯作者：
Loor JJ
影响因子：
4.6
作者：
Loor, Juan J.;Everts, Robin E.;Lewin, Harris A.
通讯作者：
Lewin, Harris A.
影响因子：
29
作者：
Holland WL;Adams AC;Brozinick JT;Bui HH;Miyauchi Y;Kusminski CM;Bauer SM;Wade M;Singhal E;Cheng CC;Volk K;Kuo MS;Gordillo R;Kharitonenkov A;Scherer PE
通讯作者：
Scherer PE
影响因子：
29
作者：
Badman, Michael K.;Pissios, Pavlos;Maratos-Flier, Eleftheria
通讯作者：
Maratos-Flier, Eleftheria
影响因子：
2.1
作者：
De Koster, J.;Urh, C.;Opsomer, G.
通讯作者：
Opsomer, G.