Sense and sensibility: flagellum-mediated gene regulation.
Sense and sensibility: flagellum-mediated gene regulation.
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DOI：
10.1016/j.tim.2009.11.001
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发表时间：
2010-01
影响因子：
15.9
通讯作者：
Hoover TR
中科院分区：
文献类型：
--
作者：
Anderson JK;Smith TG;Hoover TR
鞭毛是许多细菌运动所需的旋转发动机，在基因表达中发挥着关键作用。一段时间以来，人们已经知道鞭毛亚结构充当协调鞭毛基因表达与组装的检查点。然而，人们对基因表达的其他更全面的影响还不太了解。例如，鞭毛在鼠伤寒沙门氏菌中充当“湿度”传感器，在其他细菌中充当机械传感器。此外，它还参与多种细菌过程，包括生物膜形成、发病机制和共生。尽管对于许多这些过程来说，可能只是需要运动性，但对于其他情况，鞭毛在调节基因表达方面似乎发挥着未被充分认识的作用。
The flagellum, a rotary engine required for motility in many bacteria, plays key roles in gene expression. It has been known for some time that flagellar substructures serve as checkpoints that coordinate flagellar gene expression with assembly. Less well understood, however, are other more global effects on gene expression. For instance, the flagellum acts as a ‘wetness’ sensor in Salmonella typhimurium and as a mechanosensor in other bacteria. Additionally, it has been implicated in a variety of bacterial processes, including biofilm formation, pathogenesis and symbiosis. Although for many of these processes it may be simply that motility is required, for other cases it seems that the flagellum plays an underappreciated role in regulating gene expression.
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