A molecular framework controlling style morphology in Brassicaceae.
A molecular framework controlling style morphology in Brassicaceae.
复制标题
控制十字花科花柱形态的分子框架。
DOI：
10.1242/dev.158105
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发表时间：
2018-03-01
期刊：
影响因子：
--
通讯作者：
Østergaard L
中科院分区：
文献类型：
--
作者：
Simonini S;Stephenson P;Østergaard L
多细胞生物体中器官的形成依赖于调控成分的协调活动，这些调控成分整合发育和激素信号来控制基因表达和调节细胞类型规范。例如，拟南芥雌蕊的发育受到植物激素生长素的分布和合成的严格控制。在雌蕊群发育过程中，几种转录因子(TF)的功能与生长素动态相关，但它们的活性如何协调尚不清楚。在这里，我们表明，五个这样的TF共同作用，以确保在雌蕊顶端建立极性。生长素反应因子ETTIN(ARF3；这里是ETT)是这个框架的中心组成部分。ETT与TF伴侣的相互作用对生长素的存在很敏感，我们的结果表明ETT形成了抑制性基因调控复合体的一部分。我们证明这一功能在十字花科成员之间是保守的，并且ETT亚域的变异影响相互作用强度和雌蕊形态。这些结果表明，保守的TF之间亲和力的差异可以导致形态上的差异，从而有助于不同器官形状的进化。摘要：含有ETTIN的复合体转录因子之间相互作用亲和力的差异是十字花科成员雌蕊草花柱结构多样性的基础。
Organ formation in multicellular organisms depends on the coordinated activities of regulatory components that integrate developmental and hormonal cues to control gene expression and mediate cell-type specification. For example, development of the Arabidopsis gynoecium is tightly controlled by distribution and synthesis of the plant hormone auxin. The functions of several transcription factors (TFs) have been linked with auxin dynamics during gynoecium development; yet how their activities are coordinated is not known. Here, we show that five such TFs function together to ensure polarity establishment at the gynoecium apex. The auxin response factor ETTIN (ARF3; herein, ETT) is a central component of this framework. Interaction of ETT with TF partners is sensitive to the presence of auxin and our results suggest that ETT forms part of a repressive gene-regulatory complex. We show that this function is conserved between members of the Brassicaceae family and that variation in an ETT subdomain affects interaction strengths and gynoecium morphology. These results suggest that variation in affinities between conserved TFs can lead to morphological differences and thus contribute to the evolution of diverse organ shapes. Summary: Variation in interaction affinity between transcription factors of an ETTIN-containing complex underlies diversity of gynoecium style structure among members of the Brassicacea family.
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影响因子：
3.7
作者：
Belda-Palazón B;Ruiz L;Martí E;Tárraga S;Tiburcio AF;Culiáñez F;Farràs R;Carrasco P;Ferrando A
通讯作者：
Ferrando A
影响因子：
4.5
作者：
González-Reig S;Ripoll JJ;Vera A;Yanofsky MF;Martínez-Laborda A
通讯作者：
Martínez-Laborda A
DOI：
10.1073/pnas.1316278111
发表时间：
2014-02-11
影响因子：
11.1
作者：
Franco-Zorrilla, Jose M.;Lopez-Vidriero, Irene;Solano, Roberto
通讯作者：
Solano, Roberto
影响因子：
7.4
作者：
Bao, Fang;Azhakanandam, Sridevi;Franks, Robert G.
通讯作者：
Franks, Robert G.
影响因子：
4.5
作者：
Reyes-Olalde JI;Zúñiga-Mayo VM;Serwatowska J;Chavez Montes RA;Lozano-Sotomayor P;Herrera-Ubaldo H;Gonzalez-Aguilera KL;Ballester P;Ripoll JJ;Ezquer I;Paolo D;Heyl A;Colombo L;Yanofsky MF;Ferrandiz C;Marsch-Martínez N;de Folter S
通讯作者：
de Folter S