KIR diversity in three ethnic minority populations in China.
KIR diversity in three ethnic minority populations in China.
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DOI：
10.1186/s12967-015-0544-7
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发表时间：
2015-07-11
影响因子：
7.4
通讯作者：
Ma F
中科院分区：
文献类型：
--
作者：
Zhou Q;Wang J;He Z;Li X;Mao S;Huang S;Bian G;Ma F
杀伤细胞免疫球蛋白样受体（KIRs）在不同人群中在基因含量和等位基因多态性方面表现出广泛的差异。
我们分析了中国拉萨市藏族、乌鲁木齐市维吾尔族和哈萨克族人群中KIR基因的分布情况。采用多重聚合酶链反应 - 序列特异性引物（PCR - SSP）方法对479名随机选取的个体进行了16种KIR基因的基因分型检测。
共检测到42种KIR基因型，其中29种被预测为AB基因型，12种为BB基因型，1种为AA基因型。在哈萨克族中鉴定出27种KIR基因型，在维吾尔族中鉴定出30种KIR基因型，在藏族中鉴定出20种KIR基因型。主要基因型1（AA基因型）在藏族（52.7%，118/224）、哈萨克族（43.2%，54/125）和维吾尔族（34.9%，45/130）中出现的频率最高。不仅所有个体都存在4种框架基因，而且在所有维吾尔族个体中都能检测到假基因2DP1。藏族在KIR基因含量和KIR等位基因变异方面与哈萨克族和维吾尔族群体不同。有趣的是，与维吾尔族（60.8%，79/130）和哈萨克族（59.2%，74/125）相比，藏族（29.5%，66/224）中2DS4 - v的频率较低。维吾尔族（25.4%，33/130）中具有C4Tx（缺失KIR3DS1 - 2DL5 - 2DS5 - 2DS1）的Bx基因型频率高于哈萨克族（11.2%，14/125）和藏族（3.6%，8/224）。
该研究表明，中国三个少数民族人群的KIR基因型图谱呈现出种族多样性。这对于丰富KIR基因的种族信息资源以及促进KIR相关疾病的进一步研究可能具有重要价值。
本文的网络版（doi:10.1186/s12967 - 015 - 0544 - 7）包含补充材料，授权用户可获取。
Killer cell immunoglobulin-like receptors (KIRs) show extensive variation in genetic content and allelic polymorphi sms among different populations. We analyzed the distribution of KIR genes in the Tibetan ethnic minority of Lhasa city, the Uyghur and Kazakh ethnic minorities of Urumqi city populations in China. Genotyping of 16 KIR genes was tested in 479 randomly selected individuals using the multiple PCR-SSP method. A total of 42 KIR genotypes were detected, of which, 29 were predicted to be AB genotypes, 12 were BB genotypes and one was AA genotypes. 27 KIR genotypes were identified in Kazakhs, 30 KIR genotypes were identified in Uyghurs and 20 KIR genotypes were identified in Tibetans. The predominant genotype 1(AA genotypes) occurred most frequently in Tibetans (52.7%, 118/224), Kazakhs (43.2%, 54/125) and Uyghurs (34.9%, 45/130). Not only the four framework genes were present in all individuals, but the pseudogene 2DP1 could also be detected in all Uyghur individuals. Tibetans were different from Kazakh and Uyghur groups in KIR genetic content and KIR allelic variation. Intriguingly, Tibetans (29.5%, 66/224) had lower frequencies of 2DS4-v when compared with Uyghurs (60.8%, 79/130) and Kazakh s (59.2%, 74/125). Uyghurs (25.4%, 33/130) displayed higher frequencies of Bx genotypes with C4Tx (absence of KIR3DS1-2DL5-2DS5-2DS1) than both Kazakhs (11.2%, 14/125) and Tibetans (3.6%, 8/224). The study showed that profile of KIR genotypes in three ethnic minority populations in China displayed ethnic diversity. It could be valuable for enriching the ethnical information resources for KIR gene, as well as facilitating further research on KIR-related diseases. The online version of this article (doi:10.1186/s12967-015-0544-7) contains supplementary material, which is available to authorized users.
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影响因子：
6.4
作者：
Merino, Aimee;Malhotra, Rakhi;Kaslow, Richard A.
通讯作者：
Kaslow, Richard A.
影响因子：
2.7
作者：
McQueen, Karina L.;Dorighi, Kristel M.;Parham, Peter
通讯作者：
Parham, Peter
中国汉族人群杀伤细胞免疫球蛋白样受体（KIR）基因型和单倍型的特征
影响因子：
--
作者：
Bao, X.;Wang, M.;He, J.
通讯作者：
He, J.
DOI：
10.1016/j.bbmt.2011.04.008
发表时间：
2011-11
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Gallez-Hawkins GM;Franck AE;Li X;Thao L;Oki A;Gendzekhadze K;Dagis A;Palmer J;Nakamura R;Forman SJ;Senitzer D;Zaia JA
通讯作者：
Zaia JA
影响因子：
10.7
作者：
SAITOU, N;NEI, M
通讯作者：
NEI, M