Association between PD-L1 expression combined with tumor-infiltrating lymphocytes and the prognosis of patients with advanced hypopharyngeal squamous cell carcinoma.
Association between PD-L1 expression combined with tumor-infiltrating lymphocytes and the prognosis of patients with advanced hypopharyngeal squamous cell carcinoma.
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DOI：
10.18632/oncotarget.21564
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发表时间：
2017-11-03
期刊：
影响因子：
--
通讯作者：
Hirohito U
中科院分区：
文献类型：
--
作者：
Ono T;Azuma K;Kawahara A;Sasada T;Hattori S;Sato F;Shin B;Chitose SI;Akiba J;Hirohito U
关于晚期下咽鳞状细胞癌（HPSCC）患者的免疫相关预后因素的信息有限。肿瘤细胞中程序性细胞死亡配体 1 (PD-L1) 的表达有助于建立一种允许癌细胞逃避免疫监视的机制。我们研究了肿瘤细胞中 PD-L1 或人类白细胞抗原 (HLA) I 类表达以及肿瘤浸润淋巴细胞 (TIL) 密度是否与肿瘤对新辅助化疗 (NAC) 的反应和晚期 HPSCC 患者的生存相关。我们回顾性分析了 83 名连续接受 NAC 治疗的 III 期或 IV 期 HPSCC 患者。我们使用免疫组织化学评估了 PD-L1 和 HLA I 类表达以及 TIL 密度。单变量和多变量分析表明，CD8+ TIL 密度是 NAC 反应、无进展生存期 (PFS) 和总生存期 (OS) 的独立且显着的预测因素，而 PD-L1 或 HLA I 类表达没有显着相关性。亚组分析显示，未检测到 PD-L1 表达的较高 CD8+ TIL 密度往往与较长的患者生存期相关。这些结果表明，PD-L1 表达水平与 CD8+ TIL 密度相结合可以作为接受 NAC 的 III 期或 IV 期 HPSCC 患者的预测生物标志物。
Limited information is available regarding the immune-related prognostic factors of patients with advanced hypopharyngeal squamous cell carcinoma (HPSCC). The expression of programmed cell death-ligand 1 (PD-L1) in tumor cells contributes to a mechanism that allows cancer cells to escape immune surveillance. We investigated whether PD-L1 or human leukocyte antigen (HLA) class I expression in tumor cells and the tumor-infiltrating lymphocyte (TIL) density were associated with the tumor response to neoadjuvant chemotherapy (NAC) and survival in patients with advanced HPSCC. We retrospectively reviewed 83 consecutive patients with stage III or IV HPSCC who received NAC. We evaluated PD-L1 and HLA class I expression and TIL density using immunohistochemistry. Univariate and multivariate analyses demonstrated that CD8+ TIL density was an independent and significant predictive factor for the response to NAC, progression-free survival (PFS) and overall survival (OS), whereas PD-L1 or HLA class I expression did not significantly correlate. The subgroup analysis revealed that a higher CD8+ TIL density without detectable PD-L1 expression tended to be associated with longer patient survival. These results suggest that PD-L1 expression levels combined with CD8+ TIL density may serve as a predictive biomarker for patients with stage III or IV HPSCC receiving NAC.
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影响因子：
2
作者：
Motoshima T;Komohara Y;Ma C;Dewi AK;Noguchi H;Yamada S;Nakayama T;Kitada S;Kawano Y;Takahashi W;Sugimoto M;Takeya M;Fujimoto N;Oda Y;Eto M
通讯作者：
Eto M
DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
11.2
作者：
Kang TH;Mao CP;Lee SY;Chen A;Lee JH;Kim TW;Alvarez RD;Roden RB;Pardoll D;Hung CF;Wu TC
通讯作者：
Wu TC
影响因子：
4.6
作者：
Kim HU;Kim HY;Kulkarni A;Ahn C;Jin Y;Kim Y;Lee KN;Lee MH;Kim T
通讯作者：
Kim T
影响因子：
8.8
作者：
Balermpas, P;Michel, Y;Wagenblast, J;Seitz, O;Weiss, C;Rodel, F;Rodel, C;Fokas, E
通讯作者：
Fokas, E