Emerging therapies in Parkinson disease - repurposed drugs and new approaches.
Emerging therapies in Parkinson disease - repurposed drugs and new approaches.
复制标题
DOI：
10.1038/s41582-019-0155-7
复制
发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Okun MS
中科院分区：
文献类型：
--
作者：
Elkouzi A;Vedam-Mai V;Eisinger RS;Okun MS
“”
Parkinson disease (PD) treatment options have conventionally focused on dopamine replacement and provision of symptomatic relief. Current treatments cause undesirable adverse effects, and a large unmet clinical need remains for treatments that offer disease modification and that address symptoms resistant to levodopa. Advances in high-throughput drug screening methods for small molecules, developments in disease modelling and improvements in analytical technologies have collectively contributed to the emergence of novel compounds, repurposed drugs and new technologies. In this Review, we focus on disease-modifying and symptomatic therapies under development for PD. We review cellular therapies and repurposed drugs, such as nilotinib, inosine, isradipine, iron chelators and anti-inflammatories, and discuss how their success in preclinical models has paved the way for clinical trials. We provide an update on immunotherapies and vaccines. In addition, we review non-pharmacological interventions targeting motor symptoms, including gene therapy, adaptive deep brain stimulation (DBS) and optogenetically inspired DBS. Given the many clinical phenotypes of PD, individualization of therapy and precision of treatment are likely to become important in the future.
登录
查看更多内容
DOI：
10.1016/s0140-6736(17)31585-4
发表时间：
2017-10-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Athauda D;Maclagan K;Skene SS;Bajwa-Joseph M;Letchford D;Chowdhury K;Hibbert S;Budnik N;Zampedri L;Dickson J;Li Y;Aviles-Olmos I;Warner TT;Limousin P;Lees AJ;Greig NH;Tebbs S;Foltynie T
通讯作者：
Foltynie T
影响因子：
2.3
作者：
Bendikov-Bar, Inna;Maor, Gali;Filocamo, Mirella;Horowitz, Mia
通讯作者：
Horowitz, Mia
影响因子：
16.2
作者：
Bendor JT;Logan TP;Edwards RH
通讯作者：
Edwards RH
影响因子：
29
作者：
Beal, M. Flint;Oakes, David;Boyar, Karyn
通讯作者：
Boyar, Karyn
影响因子：
9.9
作者：
Bibbiani, F;Oh, JD;Chase, TN
通讯作者：
Chase, TN