Clinical, biologic, and behavioral predictors of early immunologic and virologic response in HIV-infected patients initiating protease inhibitors.
Clinical, biologic, and behavioral predictors of early immunologic and virologic response in HIV-infected patients initiating protease inhibitors.
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启动蛋白酶抑制剂的 HIV 感染患者早期免疫学和病毒学反应的临床、生物学和行为预测因子。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
C. Leport
中科院分区：
文献类型：
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作者：
V. Moing;G. Chêne;M. Carrieri;J. Besnier;B. Masquelier;R. Salamon;C. Bazin;J. Moatti;F. Raffi;C. Leport
在750例HIV-1感染患者中研究了治疗4个月（M4）后病毒学（血浆HIV RNA病毒载量[VL] 50个细胞/mm 3）应答的预测因素，这些患者在含蛋白酶抑制剂（PI）方案开始时前瞻性入组。在80%的患者中观察到病毒学应答，在64%的患者中观察到免疫学应答。62%的患者自我报告在治疗1个月（M1）和M4时完全依从治疗。在多变量分析中，病毒学应答在完全依从的患者中更常见（比值比[OR] = 2.0; p = 0.001）。免疫应答与年龄<36岁相关（OR = 1.4：p =.03），基线VL（OR = 1.5/1 log 10拷贝/ml升高; p <.01），M1时VL降低（OR = 1.5/1 log 10拷贝/ml降低; p <.01），基线总淋巴细胞计数（OR = 1.7/50%降低; p <0.001）和基线CD 4+细胞百分比≥20%（OR = 1.9; p <0.001），但不依从治疗。完全依从性似乎是含PI三联疗法病毒学应答的主要预测因素。免疫应答可能是可能的，尽管不完全遵守，至少在治疗早期。
Predictors of virologic (plasma HIV RNA viral load [VL] 50 cells/mm 3 ) response after 4 months of therapy (M4) were studied in 750 HIV-1-infected patients prospectively enrolled at the initiation of a protease inhibitor (PI)-containing regimen. A virologic response was observed in 80% of patients, and an immunologic response was observed in 64%. Sixty-two percent of patients self-reported full adherence to therapy at 1 month of therapy (M I ) and M4. In multivariate analysis, a virologic response was more frequent in fully adherent patients (odds ratio [OR] = 2.0; p =.001). An immunologic response was associated with age <36 years (OR = 1.4: p =.03), baseline VL (OR = 1.5 per 1 log 10 copies/ml higher; p <.01), decrease in VL at M1 (OR = 1.5 per 1 log 10 copies/ml decrease; p <.01), baseline total lymphocyte count (OR = 1.7 per 50% lower; p <.001), and baseline CD4 + cell percentage ≥20% (OR = 1.9; p <.001) but not with adherence to therapy. Full adherence seems to be a major predictor of a virologic response to PI-containing triple therapy. An immunologic response may be possible despite incomplete adherence, at least early in therapy.
城市退伍军人事务医疗中心的艾滋病毒感染的蛋白酶抑制剂治疗的疾病进展、依从性和反应。
DOI：
10.1097/00126334-199912010-00006
发表时间：
1999
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
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作者：
Maher,K;Klimas,N;Fletcher,MA;Cohen,V;Maggio,CM;Triplett,J;Valenzuela,R;Dickinson,G
通讯作者：
Dickinson,G
接受多药抗逆转录病毒治疗方案的患者自我报告的依从性和血浆 HIV 浓度的预测因素。
DOI：
10.1097/00126334-200004150-00005
发表时间：
2000
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
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作者：
Gifford,AL;Bormann,JE;Shively,MJ;Wright,BC;Richman,DD;Bozzette,SA
通讯作者：
Bozzette,SA
年龄、病毒载量和 CD4 计数对 HIV-1 感染进展为 AIDS 的速度有影响。
DOI：
10.1097/00042560-199707010-00009
发表时间：
1997
期刊：
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
影响因子：
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作者：
Operskalski,EA;Mosley,JW;Busch,MP;Stram,DO
通讯作者：
Stram,DO