On the mechanism of the involvement of endothelium in reactive hyperemia
On the mechanism of the involvement of endothelium in reactive hyperemia
复制标题
内皮细胞参与反应性充血的机制研究
DOI：
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复制
发表时间：
1991
期刊：
影响因子：
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通讯作者：
M. N. Tkachenko
中科院分区：
文献类型：
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作者：
V. Sagach;M. N. Tkachenko
在麻醉犬和血管试验准备上的实验表明，反应性充血(RH)伴随着血液中血管扩张剂的出现，并且随着动脉阻断时间的延长而增加。用皂苷去除部分血管床内皮，可降低受试制剂的相对湿度和舒张度。血管床内压力的升高，以及二聚戊二醛预处理导致的内皮变形性的降低，都以类似的方式影响充血和血管制剂的反应。结论：血管内压下降是血管内皮细胞分泌血管活性物质的结果。
Experiments on anesthetized dogs and on vascular test-preparations demonstrated that reactive hyperemia (RH) was accompanied by the appearance of vasodilator in the blood, and that the level increased with the duration of occlusion of the artery. Removal of the endothelium of the part of the vascular bed studied using saponin, decreased the RH and relaxation of a test-preparation. A rise of pressure in the vascular bed, and a decrease in the deformability of the endothelium resulting from pretreatment with dimerized glutaraldehyde, affected both the hyperemia and the reaction of the vascular preparation in a similar way. It was concluded that the RH resulted from the secretion of vasoactive substances by the endothelium in response to a fall in intravascular pressure.
内皮依赖性压力引起的离体犬颈动脉收缩。
DOI：
10.1152/ajpheart.1988.255.4.h783
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
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作者：
Rubanyi,GM
通讯作者：
Rubanyi,GM
患有主动脉缩窄高血压的兔子的内皮依赖性舒张受损。
DOI：
10.1161/01.hyp.10.2.164
发表时间：
1987
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
Miller,MJ;Pinto,A;Mullane,KM
通讯作者：
Mullane,KM