Ryanodine receptor and immune-related molecules in diabetic cardiomyopathy.
Ryanodine receptor and immune-related molecules in diabetic cardiomyopathy.
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兰尼定受体和免疫相关分子与糖尿病心肌病的关系。
DOI：
10.1002/ehf2.13431
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发表时间：
2021-08
影响因子：
3.8
通讯作者：
Zhen Z
中科院分区：
文献类型：
--
作者：
Tian CJ;Zhang JH;Liu J;Ma Z;Zhen Z
高血糖是糖尿病心肌病发生的主要病因。过高的血糖会增加心脏中活性羰基（RCS）、活性氧（ROS）和活性氮（RNS）的水平，并导致钙稳态紊乱、炎症和免疫系统紊乱。 Ryanodine 受体 2 (RyR2) 在心脏收缩期间的兴奋-收缩耦合中发挥关键作用，包括心脏的节律性收缩和舒张。白细胞介素 1 (IL-1) 信号已部分表明心脏炎症，支持 B 和 T 淋巴细胞在糖尿病心肌病中的作用。已知 RCS、ROS 和 RNS 应激对兰尼碱受体 (RyR) 的一些翻译后修饰会影响其门控和 Ca2+ 敏感性，从而导致糖尿病心肌病中 RyR 失调。 RyR 和免疫相关分子是各种心脏和心血管疾病的许多生理和病理生理过程中的重要信号物质。然而，关于糖尿病中 RyR 与免疫相关分子之间的机制关系，以及介导心肌细胞、成纤维细胞和免疫细胞之间复杂通讯的机制，人们知之甚少。这篇综述重点介绍了糖尿病心肌病发病机制和进展中复杂细胞通讯的新发现。我们讨论了针对 RyR 和免疫相关分子在糖尿病并发症中的潜在治疗应用。
Hyperglycaemia is a major aetiological factor in the development of diabetic cardiomyopathy. Excessive hyperglycaemia increases the levels of reactive carbonyl species (RCS), reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the heart and causes derangements in calcium homeostasis, inflammation and immune‐system disorders. Ryanodine receptor 2 (RyR2) plays a key role in excitation–contraction coupling during heart contractions, including rhythmic contraction and relaxation of the heart. Cardiac inflammation has been indicated in part though interleukin 1 (IL‐1) signals, supporting a role for B and T lymphocytes in diabetic cardiomyopathy. Some of the post‐translational modifications of the ryanodine receptor (RyR) by RCS, ROS and RNS stress are known to affect its gating and Ca2+ sensitivity, which contributes to RyR dysregulation in diabetic cardiomyopathy. RyRs and immune‐related molecules are important signalling species in many physiological and pathophysiological processes in various heart and cardiovascular diseases. However, little is known regarding the mechanistic relationship between RyRs and immune‐related molecules in diabetes, as well as the mechanisms mediating complex communication among cardiomyocytes, fibroblasts and immune cells. This review highlights new findings on the complex cellular communications in the pathogenesis and progression of diabetic cardiomyopathy. We discuss potential therapeutic applications targeting RyRs and immune‐related molecules in diabetic complications.
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影响因子：
4
作者：
Bajpai A;Tilley DG
通讯作者：
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影响因子：
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