Drosophila Psf2 has a role in chromosome condensation.
Drosophila Psf2 has a role in chromosome condensation.
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DOI：
10.1007/s00412-012-0383-8
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发表时间：
2012-12
期刊：
影响因子：
1.6
通讯作者：
Christensen TW
中科院分区：
文献类型：
--
作者：
Chmielewski JP;Henderson L;Smith CM;Christensen TW
染色体的凝聚状态是细胞内多个过程的关键参数。不能维持适当的缩合状态可能导致基因组不稳定、基因错误表达和一些疾病状态。在细胞增殖过程中，DNA的复制对染色体包装来说是一个持续的挑战，因为DNA必须拆开包装进行复制，然后再忠实地重新包装。DNA复制机制的一个不可或缺的成员是GINS复合体，它已被证明可以稳定CMG复合体，而CMG复合体是Mcm2-7解旋酶复合体在S期的加工能力所必需的。通过对Psf2（进化上保守的GINS复合体的成员）零突变相关表型的研究，我们发现果蝇Psf2可能在建立染色体凝聚中起作用，并且与这种错误凝聚相关的缺陷影响M期进展、基因组稳定性和转录调控。
The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, and a number of disease states. During cell proliferation, replication of DNA represents an ongoing challenge for chromosome packaging as DNA must be unpackaged for replication and then faithfully repackaged. An integral member of the DNA replication machinery is the GINS complex which has been shown to stabilize the CMG complex which is required for processivity of the Mcm2–7 helicase complex during S phase. Through examination of the phenotypes associated with a null mutation in Psf2, a member of the evolutionarily conserved GINS complex, we find that Drosophila Psf2 likely has a role in establishing chromosome condensation and that the defects associated with this mis-condensation impact M phase progression, genomic stability, and transcriptional regulation.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
21.3
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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作者：
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