Dysplastic nevus in histologic contiguity with acquired nonfamilial melanoma. Clinicopathologic experience in a 100-bed hospital.
Dysplastic nevus in histologic contiguity with acquired nonfamilial melanoma. Clinicopathologic experience in a 100-bed hospital.
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组织学上与获得性非家族性黑色素瘤邻近的发育不良痣。
作者：
P. Duray;M. Ernstoff
面对世界范围内黑色素瘤惊人的增长率，发育不良痣，特别是任何在临床上改变大小，颜色或边界的痣，可能被认为在肿瘤阶段的进展中发挥了潜在的作用。已知发育不良痣在遗传性恶性黑色素瘤家族成员中多发。表皮内非典型黑色素细胞符合发育不良痣的标准，在组织学上与浅表恶性非家族性黑色素瘤相邻的13例患者中有6例。除了一个例外，本研究中所有与组织学连续发育不良痣相关的黑色素瘤都相对较薄，允许在潜在可治愈阶段识别黑色素瘤。
In the face of alarming rates of increase in melanoma worldwide, dysplastic nevi, especially any that are clinically changing in size, color, or borders, may be regarded as playing a potential role in the progression to a tumor stage. Dysplastic nevi are known to occur in multiples in family members of heritable malignant melanoma. Intraepidermal atypical melanocytes fulfilling the criteria of the dysplastic nevus were seen in histologic contiguity with superficial malignant nonfamilial melanomas in six of 13 patients. With one exception, all melanomas in this study that were associated with histologically contiguous dysplastic nevi were relatively thin, allowing identification of the melanoma at a potentially curable stage.
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发育不良痣综合征：我们的定义。
DOI：
10.1097/00000372-198210000-00014
发表时间：
1982
期刊：
The American Journal of dermatopathology
影响因子：
--
作者：
Elder,DE;Green,MH;Guerry4th,D;Kraemer,KH;ClarkJr,WH
通讯作者：
ClarkJr,WH
影响因子：
3.3
作者：
CLARK, WH;ELDER, DE;VANHORN, M
通讯作者：
VANHORN, M
患有发育异常痣的黑色素瘤易发家庭患恶性黑色素瘤的风险较高。
影响因子：
39.2
作者：
Greene,MH;ClarkJr,WH;Tucker,MA;Kraemer,KH;Elder,DE;Fraser,MC
通讯作者：
Fraser,MC
黑色素瘤分类：可检验的假设。
DOI：
10.1097/00000372-198210000-00011
发表时间：
1982
期刊：
The American Journal of dermatopathology
影响因子：
--
作者：
Elder,DE;Jucovy,PM;ClarkJr,WH
通讯作者：
ClarkJr,WH