Non-Dipper Pattern is a Determinant of the Inappropriateness of Left Ventricular Mass in Essential Hypertensive Patients.
Non-Dipper Pattern is a Determinant of the Inappropriateness of Left Ventricular Mass in Essential Hypertensive Patients.
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DOI：
10.4070/kcj.2011.41.4.191
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发表时间：
2011-04
影响因子：
2.9
通讯作者：
Shin J
中科院分区：
文献类型：
--
作者：
Kim BK;Lim YH;Lee HT;Lee JU;Kim KS;Kim SG;Kim JH;Lim HK;Shin J
已知不适当的高左心室质量（iLVM）与心血管预后有关。非倾斗型高血压患者的平均左室（LV）质量大于倾斗型。然而，左室质量在斗或非斗模式下的适用性尚未得到充分的研究。本研究的目的是确定夜间倾斜与左室肿块适宜性之间的关系。利用动态血压监测（ABPM）数据库，回顾性分析361例接受动态血压监测和超声心动图检查的患者的数据。左室质量的适宜性计算为观察/预测的左室质量比（OPR），使用韩国指定的方程。夜间血压下降表示为夜间与白天相比收缩压（BP）下降的百分比。高血压患者白天、夜间和24小时血压分别为140.4±14.8 mmHg、143.7±15.2 mmHg和129.4±20.0 mmHg。OPR为106.3±19.9%，夜间血压为10.2±10.9 mmHg。在多元线性回归模型中，24小时收缩压（β=0.097, p=0.043）和夜间血压（β=-0.098, p=0.046）、年龄（β=0.130, p=0.025）和体重指数（BMI） （β=0.363, p<0.001）是OPR的独立决定因素。非倾斗模式的优势比为，iLVM为2.134 (p=0.021)，肥胖为3.694 （p<0.001； BMI为25 kg/m2）。非倾斜模式与高血压患者和肥胖患者的iLVM独立相关。
Inappropriately high left ventricular mass (iLVM) is known to be related to cardiovascular prognosis. A non-dipper pattern has a greater mean left ventricular (LV) mass than the dipper pattern in hypertensive patients. However, the appropriateness of LV mass in dipper or non-dipper patterns has not been adequately investigated. The aim of this study was to define the relationship between nocturnal dipping and the appropriateness of LV mass. Using the ambulatory blood pressure monitoring (ABPM) database, the data of 361 patients who underwent ABPM and echocardiography was analyzed retrospectively. Appropriateness of LV mass was calculated as observed/predicted ratio of LV mass (OPR) using a Korean-specified equation. Nocturnal dipping was expressed as percent fall in systolic blood pressure (BP) during the night compared to the day. Daytime, nighttime and 24 hours BP in hypertensive patients was 140.4±14.8 mmHg, 143.7±15.2 mmHg and 129.4±20.0 mmHg, respectively. OPR was 106.3±19.9% and nocturnal dipping was 10.2±10.9 mmHg. In a multiple linear regression model, 24 hours systolic BP (β=0.097, p=0.043) and nocturnal dipping (β=-0.098, p=0.046) were independent determinants of OPR as well as age (β=0.130, p=0.025) and body mass index (BMI) (β=0.363, p<0.001). Odds ratio of the non-dipper pattern was 2.134 for iLVM (p=0.021) and 3.694 for obesity (p<0.001; BMI >25 kg/m2). The non-dipper pattern is independently associated with iLVM in hypertensive patients as well as obesity.
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影响因子：
37.8
作者：
Devereux, RB;Roman, MJ;Howard, BV
通讯作者：
Howard, BV
影响因子：
8.3
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
8.3
作者：
de Simone, G;Devereux, RB;Daniels, SR
通讯作者：
Daniels, SR
影响因子：
8.3
作者：
de la Sierra, Alejandro;Redon, Josep;Ruilope, Luis M.
通讯作者：
Ruilope, Luis M.
影响因子：
2.8
作者：
Celentano, A;Palmieri, V;de Simone, G
通讯作者：
de Simone, G