Deconstructing the age-prevalence curve of alcohol dependence: why "maturing out" is only a small piece of the puzzle.
Deconstructing the age-prevalence curve of alcohol dependence: why "maturing out" is only a small piece of the puzzle.
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解构酒精依赖的年龄流行曲线：为什么“成熟”只是谜题的一小部分。
DOI：
10.1037/a0026027
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发表时间：
2012
影响因子：
4.6
通讯作者：
Sher,KennethJ
中科院分区：
文献类型：
--
作者：
Verges,Alvaro;Jackson,KristinaM;Bucholz,KathleenK;Grant,JuliaD;Trull,TimothyJ;Wood,PhillipK;Sher,KennethJ
流行病学研究一直表明，重度饮酒和酒精依赖（AD）倾向于在青春期和成年初期增加，然后在20多岁后期出现大幅下降，这种现象称为成熟。这种下降被解释为“角色不相容”的影响，即参与新的角色和活动会干扰大量饮酒的生活方式。然而，成熟主要被认为是抵消的减少，很少注意到几十年来新发或复发的减少。此外，虽然角色不相容的过程已与年轻的样本进行了研究，鲜为人知的是生活的转变（如，婚姻，父母，就业状况的变化）对AD以后的生活，以及是否观察到类似的影响。使用纵向数据从全国流行病学调查酒精和相关的条件，全国代表性的流行病学调查，我们研究了AD的稳定性和变化的模式在整个生命周期和不同年龄层的生活过渡对AD的不同影响。结果表明，AD的持续性倾向于随着年龄的增长而增加，尽管不是显著的，并且发病和复发倾向于随着年龄的增长而减少。此外，生活转型对AD病程的影响在整个生命周期中各不相同，男性和女性也不同。这些结果表明，生活的转变不同的影响模式的稳定性和变化，在年轻人与老年人，有不同的影响，男性和女性，并强调需要考虑的独特方面，每个阶段的成人发展的过程中AD。
Epidemiological studies have consistently demonstrated that heavy alcohol use and alcohol dependence (AD) tend to increase in adolescence and emerging adulthood and then show a large decline in the late 20s, a phenomenon called maturing out. This decline has been explained as an effect of “role incompatibility” in which involvement in new roles and activities interferes with a heavy drinking lifestyle. However, maturing out has been conceived mostly as a decrease in offset, with little attention paid to reductions in new onset or recurrence across decades of life. Moreover, although role incompatibility processes have been studied with young samples, little is known about the effect of life transitions (eg, marriage, parenthood, changes in employment status) on AD later in life and whether similar effects are observed. Using longitudinal data from the National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative epidemiologic survey, we examined the patterns of stability and change in AD across the life span and the differential effect of life transitions on AD across different age strata. Results showed that persistence of AD tended to increase with age, although not dramatically, and that onset and recurrence tended to decrease with age. Moreover, the effects of life transitions on the course of AD varied across the life span and were different for men and women. These results indicate that life transitions differentially affect the patterns of stability and change in younger versus older people, have a different impact for men and women, and highlight the need to consider the unique aspects of each stage of adult development on the course of AD.
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DOI：
--
发表时间：
1972
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.5
作者：
J. Goris;T. Camps;G. Defreyn;W. Merlevede
通讯作者：
W. Merlevede
影响因子：
4.1
作者：
HALESTRAP, AP;ARMSTON, AE
通讯作者：
ARMSTON, AE
胰高血糖素刺激线粒体呼吸。
DOI：
10.1016/s0021-9258(19)40904-6
发表时间：
1975
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Russell K Yamazaki
通讯作者：
Russell K Yamazaki
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影响因子：
3.9
作者：
Russell K Yamazaki;G. Graetz
通讯作者：
G. Graetz