The dephosphorylation of protein phosphatase inhibitor‐1 is controlled by the deinhibitor protein
The dephosphorylation of protein phosphatase inhibitor‐1 is controlled by the deinhibitor protein
复制标题
蛋白磷酸酶抑制剂-1 的去磷酸化由去抑制剂蛋白控制
DOI：
10.1016/0014-5793(81)80599-6
复制
发表时间：
1981
期刊：
影响因子：
3.5
通讯作者：
W. Merlevede
中科院分区：
文献类型：
--
作者：
J. Goris;T. Camps;G. Defreyn;W. Merlevede
2.材料和方法热稳定性磷酸酶抑制剂L[1 L]经蛋白激酶磷酸化后才具有活性，已在多种组织中被鉴定[12,131]，并已证实其在激素调节中的意义[14-171]。蛋白磷酸酶抑制剂L和蛋白磷酸酶调节剂(抑制物-2)对蛋白磷酸酶的抑制可以被与肝脏糖原结合的磷酸酶相关的去抑制蛋白所中和。到目前为止，抑制剂L的体外去磷酸化只在非生理浓度的Mn2+存在的情况下发生[11，13，19]。我们
2. Materials and methodsThe heat-stable phosphatase inhibitor-l[1 l] which is only active after phosphorylation by protein kinase, has been identified in a variety of tissues [12,131 and the implication of inhibitor-l in hormonal regulation has been demonstrated [14-171. The inhibition of the protein phosphatase by inhibitor-l as well as by the protein phosphatase modulator (inhibitor-2) can be neutralized by a deinhibitor protein associated with the glycogen-bound phosphatase of liver [181. To date the in vitro dephosphorylation of inhibitor-l only occurs in the presence of nonphysiological concentrations of Mn2+[11, 13, 19]. We
大鼠肝脏的潜在磷酸化酶：与热稳定抑制蛋白的关系。
DOI：
10.1111/j.1432-1033.1981.tb06398.x
发表时间：
1981
期刊：
European journal of biochemistry
影响因子：
--
作者：
Jett,MF;Hers,HG
通讯作者：
Hers,HG