Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study.
Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study.
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DOI：
10.1016/j.jand.2014.07.006
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发表时间：
2015-02
影响因子：
4.8
通讯作者：
Smoller, Jordan W.
中科院分区：
文献类型：
--
作者：
Agnew-Blais, Jessica C.;Wassertheil-Smoller, Sylvia;Kang, Jae H.;Hogan, Patricia E.;Coker, Laura H.;Snetselaar, Linda G.;Smoller, Jordan W.
较高的B族维生素(B6、B12和叶酸)摄入量是否对晚年的认知能力下降有保护作用仍不确定。几项前瞻性的观察性研究发现，较高的B族维生素摄入量与较低的痴呆症风险相关；其他研究，包括大多数补充B族维生素的试验，都没有观察到对认知的影响。我们在一大群老年妇女中研究了这个问题，这些老年妇女仔细监测了轻度认知障碍(MCI)和可能的痴呆症的发展。为了确定基础叶酸、维生素B6和/或B12的摄入量是否单独或联合与老年女性发生MCI/可能的痴呆症有关。前瞻性纵向队列研究。B维生素摄入量是使用1996年5月至1999年12月期间在基线上执行的食物频率问卷进行自我报告的。在妇女健康倡议记忆研究中，绝经后妇女(n=7,030)在基线时没有MCI/可能的痴呆症。在平均5.0年的随访中，通过严格的筛查和专家裁决，238例MCI事件和69例可能的痴呆症被确定。对社会人口学和生活方式因素进行调整的COX比例风险模型研究了B族维生素摄入量高于和低于推荐的每日摄入量与MCI/可能的痴呆症的关系。在控制了多个混杂因素后，研究基线时叶酸摄入量低于RDA与发生MCI/可能痴呆的风险增加相关(HR=2.0，95%CI：1.3，2.9)。维生素B6或B12与MCI/可能的痴呆症之间没有显著的关联，也没有证据表明这些维生素和叶酸摄入量之间存在相互作用。叶酸摄入量低于RDA可能会增加MCI/可能在以后生活中患痴呆症的风险。未来的研究应该包括叶酸补充的长期试验，以检验叶酸是否可能在以后的生活中对认知产生保护作用。
Whether higher B vitamin (B6, B12, and folate) intake is protective against cognitive decline in later life remains uncertain. Several prospective, observational studies find higher B vitamin intake to be associated with lower risk of dementia; other studies, including most trials of B vitamin supplementation, observe no effect on cognition. We examine this question in a large population of older women carefully monitored for development of mild cognitive impairment (MCI) and probable dementia. To determine whether baseline folate, vitamin B6 and/or B12 intake, alone or in combination, are associated with incident MCI/probable dementia among older women. Prospective, longitudinal cohort study. B vitamin intake was self-reported using a food frequency questionnaire administered at baseline between May 1996 and December 1999. Postmenopausal women (n=7,030) free of MCI/probable dementia at baseline in the Women’s Health Initiative Memory Study. Over a mean follow-up of 5.0 years, 238 cases of incident MCI and 69 cases of probable dementia were identified through rigorous screening and expert adjudication. Cox proportional hazard models adjusting for sociodemographic and lifestyle factors examined the association of B vitamin intake above and below the recommended daily allowance and incident MCI/probable dementia. Folate intake below the RDA at study baseline was associated with increased risk of incident MCI/probable dementia (HR=2.0, 95% CI: 1.3, 2.9), after controlling for multiple confounders. There were no significant associations between vitamins B6 or B12 and MCI/probable dementia, nor any evidence of an interaction between these vitamins and folate intake. Folate intake below the RDA may increase risk for MCI/probable dementia in later life. Future research should include long-term trials of folic acid supplementation to examine whether folate may impart a protective effect on cognition in later life.
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影响因子：
168.9
作者：
Durga, Jane;van Boxtel, Martin P. J.;Verhoef, Petra
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.94.7.3290
发表时间：
1997-04-01
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