A Hypoxia-Related lncRNA Signature Correlates with Survival and Tumor Microenvironment in Colorectal Cancer.
A Hypoxia-Related lncRNA Signature Correlates with Survival and Tumor Microenvironment in Colorectal Cancer.
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DOI：
10.1155/2022/9935705
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发表时间：
2022
影响因子：
4.1
通讯作者：
Li, Dawei
中科院分区：
文献类型：
--
作者：
Zhong, Xinyang;He, Xuefeng;Wang, Yaxian;Hu, Zijuan;Yu, Deshui;Huang, Huixia;Zhao, Senlin;Wei, Ping;Li, Dawei
低氧肿瘤微环境和长链非编码RNA（lncRNA）在癌症进展中是关键的，并且与患者的生存结果相关。然而，缺氧相关的lncRNA（HRL）在结直肠癌（CRC）发展中的作用仍然很大程度上未知。在此，我们开发了一种缺氧相关的lncRNA标签来预测患者的生存和免疫浸润。从癌症基因组图谱（TCGA）数据集获得500名CRC患者的RNA测序数据，并使用Pearson分析选择HRL。接下来，应用考克斯回归分析来构建由9个HRL组成的风险特征。该特征可以在训练、验证和整个队列中以高准确度预测CRC患者的总生存期（OS）。该特征是一个独立的风险因素，在不同的亚组中具有预测能力。功能分析揭示了不同的分子特征之间的高，低风险群体。两组对顺铂等一系列药物的敏感性不同。在该模型中，免疫检查点的表达模式在两个簇之间也不同。此外，高风险组比低风险组具有更高的免疫、基质和ESTIMATE评分以及更压抑的免疫微环境。此外，MYOSLID，在这个签名的lncRNA之一，可以显着调节大肠癌的增殖，侵袭和转移。
The hypoxic tumor microenvironment and long noncoding RNAs (lncRNAs) are pivotal in cancer progression and correlate with the survival outcome of patients. However, the role of hypoxia-related lncRNAs (HRLs) in colorectal cancer (CRC) development remains largely unknown. Herein, we developed a hypoxia-related lncRNA signature to predict patients' survival and immune infiltration. The RNA-sequencing data of 500 CRC patients were obtained from The Cancer Genome Atlas (TCGA) dataset, and HRLs were selected using Pearson's analysis. Next, the Cox regression analysis was applied to construct a risk signature consisting of 9 HRLs. This signature could predict the overall survival (OS) of CRC patients with high accuracy in training, validation, and entire cohort. This signature was an independent risk factor and exerted predictive ability in different subgroups. Functional analysis revealed different molecular features between high- and low-risk groups. A series of drugs including cisplatin showed different sensitivities between the two groups. The expression pattern of immune checkpoints was also distinct between the two clusters in this model. Furthermore, the high-risk group had higher immune, stromal, and ESTIMATE score and a more repressive immune microenvironment than the low-risk group. Moreover, MYOSLID, one of the lncRNAs in this signature, could significantly regulate the proliferation, invasion, and metastasis of CRC.
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影响因子：
5.5
作者：
Gu P;Zhang L;Wang R;Ding W;Wang W;Liu Y;Wang W;Li Z;Yan B;Sun X
通讯作者：
Sun X
影响因子：
13.8
作者：
Liberti MV;Locasale JW
通讯作者：
Locasale JW
影响因子：
7.3
作者：
Abou Khouzam R;Zaarour RF;Brodaczewska K;Azakir B;Venkatesh GH;Thiery J;Terry S;Chouaib S
通讯作者：
Chouaib S
DOI：
10.16288/j.yczz.21-416
发表时间：
2022-02-01
期刊：
Yichuan
影响因子：
--
作者：
Cheng, Min;Zhang, Jing;Zhou, Gangqiao
通讯作者：
Zhou, Gangqiao
DOI：
10.1158/1078-0432.ccr-13-0542
发表时间：
2013-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Eustace A;Mani N;Span PN;Irlam JJ;Taylor J;Betts GN;Denley H;Miller CJ;Homer JJ;Rojas AM;Hoskin PJ;Buffa FM;Harris AL;Kaanders JH;West CM
通讯作者：
West CM