Drosophila re-zero their path integrator at the center of a fictive food patch.
Drosophila re-zero their path integrator at the center of a fictive food patch.
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果蝇在虚拟食品斑块的中心重新零零。
DOI：
10.1016/j.cub.2021.08.006
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发表时间：
2021-10-25
期刊：
影响因子：
--
通讯作者：
Dickinson MH
中科院分区：
文献类型：
--
作者：
Behbahani AH;Palmer EH;Corfas RA;Dickinson MH
跟踪一个人在空间中的位置的能力是动物往返于显着位置的关键行为，其计算基础现在开始被揭开。在这里，我们在环形通道中跟踪苍蝇，因为它们执行由糖受体的光遗传学激活触发的搜索。与产生高度曲折的搜索轨迹的开放场地实验不同，我们的几何约束范式使我们能够监控果蝇靠近或远离虚构食物的决定。我们的结果表明，即使在食物点消失后，果蝇也会使用路径整合来记住食物点的位置，并且即使在竞技场周围行走一次或多次后，果蝇也可以记住以前的食物点的位置。为了确定果蝇搜索的行为算法，我们开发了多个状态转换模型，发现果蝇可能通过结合里程计和罗盘导航来跟踪它们相对于虚构食物的位置来完成路径整合。我们的结果表明，当只有一个进食点存在时，果蝇会将其路径积分器在食物处重新归零，而当在两个或多个位置经历食物时，它们会将其路径积分器调整到地点之间的中心位置。总之，这项工作提供了一个简单的实验范式和理论框架，以推进路径整合的神经基础的研究。 Behbahani 等人将环形竞技场中糖受体的光遗传学激活与基于代理的建模相结合。表明苍蝇结合里程计和指南针导航来跟踪它们相对于食物的位置。结果表明，苍蝇将其路径积分器调整到多个食物地点之间的中心位置。
The ability to keep track of one’s location in space is a critical behavior for animals navigating to and from a salient location, and its computational basis is now beginning to be unraveled. Here, we tracked flies in a ring-shaped channel as they executed bouts of search triggered by optogenetic activation of sugar receptors. Unlike experiments in open field arenas, which produce highly tortuous search trajectories, our geometrically constrained paradigm enabled us to monitor flies’ decisions to move toward or away from the fictive food. Our results suggest that flies use path integration to remember the location of a food site even after it has disappeared, and that flies can remember the location of a former food site even after walking around the arena one or more times. To determine the behavioral algorithms underlying Drosophila search, we developed multiple state transition models and found that flies likely accomplish path integration by combining odometry and compass navigation to keep track of their position relative to the fictive food. Our results indicate that whereas flies re-zero their path integrator at food when only one feeding site is present, they adjust their path integrator to a central location between sites when experiencing food at two or more locations. Together, this work provides a simple experimental paradigm and theoretical framework to advance investigations of the neural basis of path integration. Using a combination of optogenetic activation of sugar receptors in an annular-shaped arena and agent-based modeling, Behbahani et al. show that flies combine odometry and compass navigation to keep track of their position relative to food. The results show that flies adjust their path integrator to a central location between multiple food sites.
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