T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling.
T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling.
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DOI：
10.1084/jem.191.5.847
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发表时间：
2000-03-06
期刊：
影响因子：
--
通讯作者：
Strober W
中科院分区：
文献类型：
--
作者：
Nishikomori R;Ehrhardt RO;Strober W
The differentiation of CD4+ T cells into T helper type 1 (Th1) cells is driven by interleukin (IL)-12 through the IL-12 receptor β2 (IL-12Rβ2) chain, whereas differentiation into Th2 cells is driven by IL-4, which downregulates IL-12Rβ2 chain. We reexamined such differentiation using IL-12Rβ2 chain transgenic mice. We found that CD4+ T cells from such mice were able to differentiate into Th2 cells when primed with IL-4 or IL-4 plus IL-12. In the latter case, the presence of IL-4 suppressed interferon (IFN)-γ production 10–100-fold compared with cells cultured in IL-12 alone. Finally, in studies of the ability of IL-12 to convert Th2 cells bearing a competent IL-12R to the Th1 cells, we showed that: (a) T cells bearing the IL-12Rβ2 chain transgene and primed under Th2 conditions could not be converted to Th1 cells by repeated restimulation under Th1 conditions; and (b) established Th2 clones transfected with the IL-12Rβ2 chain construct continued to produce IL-4 when cultured with IL-12. These studies show that IL-4–driven Th2 differentiation can occur in the presence of persistent IL-12 signaling and that IL-4 inhibits IFN-γ production under these circumstances. They also show that established Th2 cells cannot be converted to Th1 cells via IL-12 signaling.
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对CD4（+）与CD8（+）T细胞的干扰素γ产生中转录的信号换能器和转录激活因子（Stat）4的谱系特异性需求。
影响因子：
15.3
作者：
Carter, L L;Murphy, K M
通讯作者：
Murphy, K M
影响因子：
11.4
作者：
Kubo, M;Ransom, J;Nakayama, T
通讯作者：
Nakayama, T
DOI：
10.1073/pnas.89.13.6065
发表时间：
1992-07-01
影响因子：
11.1
作者：
HSIEH, CS;HEIMBERGER, AB;MURPHY, KM
通讯作者：
MURPHY, KM
影响因子：
32.4
作者：
Bird, JJ;Brown, DR;Reiner, SL
通讯作者：
Reiner, SL
DOI：
10.1084/jem.181.5.1755
发表时间：
1995-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jacobson NG;Szabo SJ;Weber-Nordt RM;Zhong Z;Schreiber RD;Darnell JE Jr;Murphy KM
通讯作者：
Murphy KM