Obesity increases the risks of diverticulitis and diverticular bleeding.
Obesity increases the risks of diverticulitis and diverticular bleeding.
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DOI：
10.1053/j.gastro.2008.09.025
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发表时间：
2009-01
期刊：
影响因子：
29.4
通讯作者：
Giovannucci EL
中科院分区：
文献类型：
--
作者：
Strate LL;Liu YL;Aldoori WH;Syngal S;Giovannucci EL
肥胖和憩室并发症的研究是有限的。我们评估了体重指数（BMI）、腰围和腰臀比与憩室炎和憩室出血之间的关系。对47，228名男性卫生专业人员（40-75岁）进行了一项前瞻性队列研究，他们在1986年（基线）没有憩室疾病。在两年一次的随访问卷中报告新诊断的憩室病的男性被发送补充问卷。每两年记录一次体重，1987年收集腰围和臀围。在18年的随访中，我们记录了801例憩室炎和383例憩室出血。校正其他危险因素后，与BMI <21 kg/m2的男性相比，BMI ≥30 kg/m2的男性发生憩室炎的相对风险（RR）为1.78（95%置信区间[CI]，1.08-2.94），发生憩室出血的相对风险（RR）为3.19（95% CI，1.45-7.00）。腰围最高五分位的男性与腰围最低五分位的男性相比，憩室炎的多变量RR为1.56（95%CI，1.18-2.07），憩室出血的多变量RR为1.96（95%CI，1.30-2.97）。当比较最高和最低五分位数时，腰臀比也与憩室并发症的风险相关：憩室炎的多变量RR 1.62（95% CI; 1.23-2.14）和憩室出血的多变量RR 1.91（95% CI; 1.26-2.90）。调整BMI并没有改变腰臀比的相关性。在这个大型前瞻性队列中，BMI、腰围和腰臀比显著增加了憩室炎和憩室出血的风险。
Studies of obesity and diverticular complications are limited. We assessed the relationship between Body Mass Index (BMI), waist circumference and waist-to-hip ratios and diverticulitis and diverticular bleeding. A prospective cohort study was performed of 47,228 male health professionals (40–75 years old) that were free of diverticular disease in 1986 (baseline). Men reporting newly diagnosed diverticular disease on biennial follow-up questionnaires were sent supplemental questionnaires. Weight was recorded every 2 years and waist and hip circumferences were collected in 1987. We documented 801 incident cases of diverticulitis and 383 incident cases of diverticular bleeding during 18 years of follow-up. After adjustment for other risk factors, men with a BMI ≥30 kg/m2 had a relative risk (RR) of 1.78 (95% confidence interval [CI], 1.08–2.94) for diverticulitis and 3.19 (95% CI, 1.45–7.00) for diverticular bleeding, compared to men with a BMI of <21 kg/m2. Men in the highest quintile of waist circumference, compared with those in the lowest, had a multivariable RR of 1.56 (95% CI, 1.18–2.07) for diverticulitis and 1.96 (95% CI, 1.30–2.97) for diverticular bleeding. Waist-to-hip ratio was also associated with the risk of diverticular complications, when the highest and lowest quintiles were compared: multivariable RR 1.62 (95% CI; 1.23–2.14) for diverticulitis and multivariable RR 1.91 (95% CI; 1.26–2.90) for diverticular bleeding. Adjustment for BMI did not change the associations seen for waist-to-hip ratio. In this large prospective cohort, BMI, waist circumference and waist-to-hip ratio significantly increased the risks of diverticulitis and diverticular bleeding.
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影响因子：
4.3
作者：
Floch, Martin H.;White, Jonathan A.
通讯作者：
White, Jonathan A.
影响因子：
--
作者：
Anaya, DA;Flum, DR
通讯作者：
Flum, DR
影响因子：
24.5
作者：
HUGHES, LE
通讯作者：
HUGHES, LE
影响因子：
2.9
作者：
Korzenik, Joshua R.
通讯作者：
Korzenik, Joshua R.
影响因子：
24.5
作者：
MANOUSOS, O;DAY, NE;TRICHOPOULOS, D
通讯作者：
TRICHOPOULOS, D