Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation.
Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation.
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DOI：
10.1002/pros.20922
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发表时间：
2009-05-15
期刊：
影响因子：
2.8
通讯作者：
Brooks, James D.
中科院分区：
文献类型：
--
作者：
Gardner, Christopher D.;Oelrich, Beibei;Liu, Jenny P.;Feldman, David;Franke, Adrian A.;Brooks, James D.
大豆异黄酮对前列腺癌的影响可能是浓度依赖性的。大豆补充剂对前列腺组织和血清中异黄酮浓度的影响尚不清楚。评估和比较19名选择根治性前列腺切除术的前列腺癌患者前列腺组织和血清中大豆异黄酮的浓度。参与者在手术前两周（14天）随机接受每日大豆补充剂（相当于82毫克/天糖苷元）或安慰剂。手术时采集血清样本。采用HPLC/ESI-MS-MS法测定异黄酮浓度。异黄酮补充组前列腺组织总异黄酮浓度中位数（25、75百分位数）分别为2.3 μmol/L（1.2、6.9）和0.7 μmol/L（0.2、1.2）。与血清相比，该组前列腺组织中的总异黄酮浓度平均高出6倍；染料木素的组织与血清比值显著低于大豆苷元，分别为4倍与10倍，p=0.003。除了少数例外，安慰剂组的组织和血清异黄酮水平可以忽略不计。目前的研究结果表明，前列腺组织可能有能力将膳食大豆异黄酮浓缩到潜在的抗癌水平。（199字，8/19/08）
The effects of soy isoflavones on prostate cancer may be concentration dependent. The impact of soy supplementation on isoflavone concentrations in prostate tissues and serum remain unclear. To assess and compare concentrations of soy isoflavones in prostate tissue and serum among nineteen men with prostate cancer who had elected to undergo radical prostatectomy. Participants were randomized to receive either daily soy supplements (82 mg/day aglycone equivalents) or placebos for two weeks (14 days) prior to surgery. Serum samples were obtained at the time of the surgery. Isoflavone concentrations were measured by HPLC/ESI-MS-MS. The median (25th, 75th percentile) total isoflavone concentration in the isoflavone supplemented group was 2.3 μmol/L (1.2, 6.9) in the prostate tissue and 0.7 μmol/L (0.2, 1.2) in the serum. Total isoflavone concentrations in this group were an average of ∼6-fold higher in prostate tissue compared to serum; the tissue vs. serum ratio was significantly lower for genistein than daidzein, 4-fold vs. 10-fold, p=0.003. Tissue and serum levels of isoflavones among the placebo group were negligible with a few exceptions. The findings from the present study suggest that prostate tissue may have the ability to concentrate dietary soy isoflavones to potentially anti-carcinogenic levels. (199 words, 8/19/08)
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影响因子：
2.9
作者：
Franke, AA;Custer, LJ;Hundahl, SA
通讯作者：
Hundahl, SA
影响因子：
11.2
作者：
Majid, Shahana;Kikuno, Nobuyuki;Dahiya, Rajvir
通讯作者：
Dahiya, Rajvir
影响因子：
4.8
作者：
Kang, Nam Joo;Lee, Ki Won;Dong, Zigang
通讯作者：
Dong, Zigang
影响因子：
6.4
作者：
Kikuno, Nobuyuki;Shiina, Hiroaki;Dahiya, Rajvir
通讯作者：
Dahiya, Rajvir
影响因子：
23.4
作者：
Bektic, J;Berger, AP;Klocker, H
通讯作者：
Klocker, H