Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment.
Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment.
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DOI：
10.1016/j.psychres.2009.02.011
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发表时间：
2010-05-15
影响因子：
11.3
通讯作者：
Lotrich, Francis E.
中科院分区：
文献类型：
--
作者：
Franzen, Peter L.;Buysse, Daniel J.;Rabinovitz, Mordechai;Pollock, Bruce G.;Lotrich, Francis E.
在聚乙二醇干扰素-α2（IFN-α）治疗期间经常发生重度抑郁症（MDD）。确定这一人群中谁有患抑郁症的风险是至关重要的，流行病学研究表明睡眠可能与抑郁症风险有关。因此，在控制了已有的抑郁症状后，我们研究了IFN-α治疗前的睡眠质量是否能预测IFN-α治疗期间MDD的发生率。在IFN-α治疗前对患有丙型肝炎但目前无临床MDD的成人患者（n=86）进行评估，然后在治疗期间使用睡眠质量（PSQI）、抑郁（BDI）、愤怒和易怒（AIAQ）的自我报告指标以及DSM-IV轴I疾病的结构化临床访谈（SCID-I）进行前瞻性监测。在IFN-α治疗期间，19%的患者发展为MDD，19%的患者发展为亚综合征抑郁伴易怒，1例发展为躁狂。控制基线抑郁症状和既往抑郁史，治疗前睡眠质量较差（PSQI≥10）的患者发生MDD的时间较短（风险比= 10.6; 95%置信区间= 3.4-32.2;对数秩χ2=33.83，P<0.0001）或任何严重精神问题（危险比= 6.2; 95%置信区间=2.9-13.1;对数秩χ2=36.86，P<0.0001）。这些发现可能对理解、预测和预防抑郁症有重要意义，特别是在接受IFN-α治疗的个体中。
Major depressive disorder (MDD) often occurs during pegylated IFN-α2 (IFN-α) treatment. Identifying who is at risk for MDD in this population is essential, and epidemiological studies suggest that sleep may be related to depression risk. Controlling for pre-existing depression symptoms, we therefore examined whether sleep quality prior to IFN-α treatment would predict subsequent MDD incidence during IFN-α treatment. Adults with hepatitis C but without current clinical MDD (n=86) were evaluated prior to IFN-α treatment and then prospectively monitored during treatment using self-report measures of sleep quality (PSQI), depression (BDI), and anger and irritability (AIAQ), as well as with Structured Clinical Interviews for DSM-IV Axis I Disorders (SCID-I). During IFN-α treatment, 19% developed MDD, 19% developed subsyndromal depression with irritability, and one developed mania. Controlling for baseline depression symptoms and past history of depression, patients with worse sleep quality (PSQI≥10) prior to treatment had shorter time until developing MDD (Hazard ratio = 10.6; 95% Confidence Interval = 3.4–32.2; log-rank χ2=33.83, P<0.0001) or any severe psychiatric problem (Hazard ratio = 6.2; 95% Confidence Interval=2.9–13.1; log-rank χ2=36.86, P<0.0001). These findings may have important implications for understanding, predicting, and possibly preventing depression, particularly in individuals treated with IFN-α.
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影响因子：
4.7
作者：
Backhaus, J;Junghanns, K;Hohagen, F
通讯作者：
Hohagen, F
影响因子：
120.7
作者：
FORD, DE;KAMEROW, DB
通讯作者：
KAMEROW, DB
影响因子：
10.6
作者：
Fava, M;McCall, WV;Roth, T
通讯作者：
Roth, T
DOI：
10.1176/appi.ajp.2008.07121882
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Cho HJ;Lavretsky H;Olmstead R;Levin MJ;Oxman MN;Irwin MR
通讯作者：
Irwin MR
影响因子：
10.6
作者：
Breslau, N;Roth, T;Andreski, P
通讯作者：
Andreski, P