Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics.
Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics.
复制标题
碳水化合物模拟物修饰的功能化金胶体选择素结合的多价相互作用和选择性
DOI：
10.1039/c1ob05583f
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发表时间：
2011
影响因子：
3.2
通讯作者：
S. Schlecht
中科院分区：
文献类型：
--
作者：
M. Roskamp;S. Enders;F. Pfrengle;S. Yekta;V. Dekaris;J. Dernedde;H.-U. Reissig;S. Schlecht
Colloidal gold particles with functionalized organic shells were applied as novel selectin binders. The ligand shell was terminated with different monocyclic carbohydrate mimetics as simplified analogs of the sLex unit found in biological selectin ligands. The multivalent presentation of the sulfated selectin binding epitopes on the gold particles led to extremely high binding affinities towards L- and P-selectin and IC50 values in the subnanomolar range. Depending on the ring size of the sulfated carbohydrate mimetic, its substitution pattern and its configuration, different selectivities for either L-selectin or P-selectin were obtained. These selectivities were not found for gold particles with simple acyclic sulfated alcohols, diols and triols in the ligand shell. In addition, the influence of the particle size and the thickness of the hydrophobic organic shell were systematically investigated.
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影响因子：
4.3
作者：
Al-Harrasi, Ahmed;Pfrengle, Fabian;Reissig, Hans-Ulrich
通讯作者：
Reissig, Hans-Ulrich
2004/2005年南大洋印度洋区浮游动物群落空间分布
DOI：
--
发表时间：
2006
期刊：
影响因子：
--
作者：
品川牧詩;堀本奈穂;石丸隆;喜多村稔;小達恒夫;平譯享
通讯作者：
平譯享
生物系统中的多价Wechselwirkungen：Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren
DOI：
--
发表时间：
1998
期刊：
影响因子：
--
作者：
M. Mammen;S. Choi;G. M. Whitesides
通讯作者：
G. M. Whitesides
影响因子：
15
作者：
Bowman, Mary-Catherine;Ballard, T. Eric;Melander, Christian
通讯作者：
Melander, Christian
来自对映体纯 1,2-恶嗪的内部保护的氨基糖等价物：合成具有 C 支链氨基糖单元的可变构型碳水化合物。
影响因子：
--
作者：
F. Pfrengle;H. Reissig
通讯作者：
H. Reissig