Muscle deterioration due to rheumatoid arthritis: assessment by quantitative MRI and strength testing.
Muscle deterioration due to rheumatoid arthritis: assessment by quantitative MRI and strength testing.
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DOI：
10.1093/rheumatology/keaa364
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发表时间：
2021-03-02
期刊：
影响因子：
--
通讯作者：
Tan AL
中科院分区：
文献类型：
--
作者：
Farrow M;Biglands J;Tanner S;Hensor EMA;Buch MH;Emery P;Tan AL
RA patients often present with low muscle mass and decreased strength. Quantitative MRI offers a non-invasive measurement of muscle status. This study assessed whether MRI-based measurements of T2, fat fraction, diffusion tensor imaging and muscle volume can detect differences between the thigh muscles of RA patients and healthy controls, and assessed the muscle phenotype of different disease stages. Thirty-nine RA patients (13 ‘new RA’—newly diagnosed, treatment naïve, 13 ‘active RA’—persistent DAS28 >3.2 for >1 year, 13 ‘remission RA’—persistent DAS28 <2.6 for >1 year) and 13 age and gender directly matched healthy controls had an MRI scan of their dominant thigh. All participants had knee extension and flexion torque and grip strength measured. MRI T2 and fat fraction were higher in the three groups of RA patients compared with healthy controls in the thigh muscles. There were no clinically meaningful differences in the mean diffusivity. The muscle volume, handgrip strength, knee extension and flexion were lower in all three groups of RA patients compared with healthy controls. Quantitative MRI and muscle strength measurements can potentially detect differences within the muscles between RA patients and healthy controls. These differences may be seen in RA patients who are yet to start treatment, those with persistent active disease, and those who were in clinical remission. This suggests that the muscles in RA patients are affected in the early stages of the disease and that signs of muscle pathology and muscle weakness are still observed in clinical remission.
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影响因子：
4.7
作者：
Baker JF;Von Feldt J;Mostoufi-Moab S;Noaiseh G;Taratuta E;Kim W;Leonard MB
通讯作者：
Leonard MB
影响因子：
4.7
作者：
Cooney JK;Law RJ;Matschke V;Lemmey AB;Moore JP;Ahmad Y;Jones JG;Maddison P;Thom JM
通讯作者：
Thom JM
影响因子：
3.9
作者：
Grimm, A.;Meyer, H.;Quick, H. H.
通讯作者：
Quick, H. H.
影响因子：
2.6
作者：
Farrow, Matthew;Grainger, Andrew J.;Biglands, John
通讯作者：
Biglands, John
影响因子：
2.1
作者：
Engvall, I-L;Elkan, A-C;Hafstrom, I.
通讯作者：
Hafstrom, I.