Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer.
Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer.
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DOI：
10.1038/s41467-022-29235-2
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发表时间：
2022-04-01
影响因子：
16.6
通讯作者：
Ambs S
中科院分区：
文献类型：
--
作者：
Minas TZ;Candia J;Dorsey TH;Baker F;Tang W;Kiely M;Smith CJ;Zhang AL;Jordan SV;Obadi OM;Ajao A;Tettey Y;Biritwum RB;Adjei AA;Mensah JE;Hoover RN;Jenkins FJ;Kittles R;Hsing AW;Wang XW;Loffredo CA;Yates C;Cook MB;Ambs S
有证据表明，非洲裔美国人和欧洲裔美国人前列腺癌患者之间的肿瘤免疫生物学和免疫治疗反应可能不同。在这里，我们确定了非洲裔男性是否具有独特的全身免疫肿瘤学特征，并测量了近3000名加纳，非洲裔美国人和欧洲裔美国人男性的82种循环蛋白。抑制肿瘤免疫和趋化性的蛋白质特征在西非血统的男性中升高。重要的是，肿瘤免疫蛋白签名的抑制与转移性和致死性前列腺癌相关，指出了临床重要性。此外，两个标志物，多效生长因子和TNFRSF9，特别是在非洲裔美国人中预测疾病生存率差。这些发现表明，非洲裔和欧洲裔男性之间的免疫肿瘤学标志物谱不同。这些差异可能导致非洲血统男性致命前列腺癌的不成比例的负担。肿瘤免疫的外周抑制升高可能对指导癌症治疗具有重要意义，这可能特别有利于非洲裔美国患者。与免疫生物学相关的差异可以解释在前列腺癌患者中观察到的健康差异，非洲裔男性承担最高的前列腺癌负担。通过测量血清样本中的免疫相关蛋白，作者报告说，与肿瘤免疫抑制相关的全身性细胞因子在非洲血统的男性中上调，并与生存率降低相关。
There is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of African descent harbor a unique systemic immune-oncological signature and measure 82 circulating proteins in almost 3000 Ghanaian, African American, and European American men. Protein signatures for suppression of tumor immunity and chemotaxis are elevated in men of West African ancestry. Importantly, the suppression of tumor immunity protein signature associates with metastatic and lethal prostate cancer, pointing to clinical importance. Moreover, two markers, pleiotrophin and TNFRSF9, predict poor disease survival specifically among African American men. These findings indicate that immune-oncology marker profiles differ between men of African and European descent. These differences may contribute to the disproportionate burden of lethal prostate cancer in men of African ancestry. The elevated peripheral suppression of tumor immunity may have important implication for guidance of cancer therapy which could particularly benefit African American patients. Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here the authors report that systemic cytokines linked to suppression of tumor immunity are upregulated in men of African ancestry and associated with reduced survival.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
2.1
作者：
Hardiman, Gary;Savage, Stephen J.;Gattoni-Celli, Sebastiano
通讯作者：
Gattoni-Celli, Sebastiano
影响因子：
8.8
作者：
Feng, Xiaoshuang;Song, Mingyang;Mucci, Lorelei A.
通讯作者：
Mucci, Lorelei A.
DOI：
10.1158/1078-0432.ccr-20-2925
发表时间：
2021-01-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Awasthi S;Berglund A;Abraham-Miranda J;Rounbehler RJ;Kensler K;Serna A;Vidal A;You S;Freeman MR;Davicioni E;Liu Y;Karnes RJ;Klein EA;Den RB;Trock BJ;Campbell JD;Einstein DJ;Gupta R;Balk S;Lal P;Park JY;Cleveland JL;Rebbeck TR;Freedland SJ;Yamoah K
通讯作者：
Yamoah K
影响因子：
10.3
作者：
Kiely, Maeve;Milne, Ginger L.;Ambs, Stefan
通讯作者：
Ambs, Stefan