Inflammation-based Glasgow prognostic score as an independent prognostic factor in patients with angioimmunoblastic T-cell lymphoma.
Inflammation-based Glasgow prognostic score as an independent prognostic factor in patients with angioimmunoblastic T-cell lymphoma.
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基于炎症的格拉斯哥预后评分作为血管免疫母细胞 T 细胞淋巴瘤患者的独立预后因素
DOI：
10.1097/cm9.0000000000001345
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发表时间：
2021-01-15
影响因子：
6.1
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Chen GJ;Wuxiao ZJ;Liang Y;Li C;Fu BB;Wang H
血管免疫母细胞性T细胞淋巴瘤（AITL）是外周T细胞淋巴瘤（PIT）的一种侵袭性形式，预后不良。其特征为淋巴结肿大、B症状（不明原因的反复发热（通常高于38 ℃）、盗汗和6个月内不明原因的体重减轻超过10%）、多克隆高丙种球蛋白血症和自身免疫性溶血。[1]C反应蛋白（CRP）是由肝细胞合成的急性时相蛋白，是全身炎症的重要标志物。血清CRP水平不仅是霍奇金淋巴瘤的独立预后因素，也是AITL的重要独立预测因子。同时，白蛋白（ALB）用于营养评估，并作为一种抗急性期蛋白。ALB的血浆浓度在炎症和细菌感染期间降低。由ALB和CRP水平组成的格拉斯哥预后评分（GPS）已在几种常见实体瘤（包括肝细胞癌、结直肠癌和肾细胞癌）中进行了研究。[2]然而，全球定位系统在航空、工业和运输日志领域的价值并不清楚。另一方面，PIT的预后指数已被广泛用于评估各种类型的T细胞非霍奇金淋巴瘤的预后。为此，我们对中山大学附属肿瘤防治中心和海南大学附属第一医院2009 - 2019年确诊的106例AITL患者进行回顾性队列研究，探讨GPS预测AITL的价值，并比较GPS模型和PIT模型对AITL患者预后的意义。组织临床数据，包括年龄、性别、B症状、血清乳酸脱氢酶（LDH）水平、血红蛋白（Hb）水平、血小板（PLT）
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive form of peripheral T-cell lymphoma (PIT) associated with poor prognosis. It is characterized by lymph node enlargement, B symptoms (unexplained recurrent fevers (often above 38 C), night sweats, and unexplained weight loss of more than 10% within 6 months), polyclonal hypergammaglobulinemia, and autoimmune hemolysis.[1] C-reactive protein (CRP) synthesized by hepatocytes is an acute-phase protein and an important marker of systemic inflammation. Serum CRP level is not only an independent prognostic factor in Hodgkin lymphoma but also an important independent predictor of AITL. Meanwhile, albumin (ALB) is used for nutrition assessment and acts as an anti-acute phase protein. The plasma concentration of ALB decreases during inflammation and bacterial infection. The Glasgow prognostic score (GPS), consisting of ALB and CRP levels, has been studied in several common solid tumors, including hepatocellular carcinoma, colorectal cancer, and renal cell carcinoma.[2] However, the value of GPS in the realm of AITL is unclear. On the other hand, the prognosis index for PIT has been widely used to evaluate the prognosis of various types of T-cell non-Hodgkin lymphoma. Therefore, we conducted a retrospective cohort study to explore the prognostic value of GPS and to compare the prognostic significance of GPS and PIT models in patients with AITL.A retrospective analysis was performed on 106 patients with AITL diagnosed during 2009 to 2019 at the Sun Yatsen University Cancer Center and the First Affiliated Hospital of Hainan University. Organized clinical data including age, sex, B-symptoms, serum lactate dehydrogenase (LDH) level, hemoglobin (Hb) level, platelet (PLT)
影响因子：
6.1
作者：
Wang G;Zhang DM;Zhuang HY;Yin C;Liu J;Wang ZC;Cai LC;Ren MH;Xu WH;Zhang C
通讯作者：
Zhang C