Roles of Loss of Chromosome 14q Allele in the Prognosis of Renal Cell Carcinoma with C-reactive Protein Abnormity.
Roles of Loss of Chromosome 14q Allele in the Prognosis of Renal Cell Carcinoma with C-reactive Protein Abnormity.
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DOI：
10.4103/0366-6999.213962
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发表时间：
2017-09-20
影响因子：
6.1
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Wang G;Zhang DM;Zhuang HY;Yin C;Liu J;Wang ZC;Cai LC;Ren MH;Xu WH;Zhang C
肾细胞癌（RCC）常伴有副肿瘤炎性综合征（PIS）。本研究旨在探讨存活率与特定基因改变之间的关系及其可能的机制。我们回顾性研究了2014年8月至2016年2月的69例手术RCC病例，其中18例透明细胞RCC（ccRCC）显示治疗前血清C反应蛋白（CRP，A组）升高。18例中有12例出现发热。我们还选择了49例治疗前CRP正常的ccRCC患者（B组）。采用22个微卫星标记，比较A组和B组的杂合性丢失（洛）发生率。所有统计检验均为双侧检验。3 p洛缺失在A组（89%）和B组（92%）中均较常见。A组14 q洛缺失频率（16/18）高于B组（4/49），χ2 = 40.97，P < 0.0001。3 p和14 q洛是急性期反应物升高的ccRCC的特征，包括PIS，而不管是否存在转移。相反，14 q洛缺失在无PIS的晚期ccRCC中是罕见的基因组改变。Kaplan-Meier曲线显示，CRP升高组总生存率（33.3%）低于CRP升高组（6.1%，危险比=1.852，P < 0.0001）。结果表明，14 q基因的破坏不仅可能导致肿瘤宿主的炎症表现，而且可能导致生存率低下。分离14 q上的基因可能是治疗PIS相关RCC的重要目标。
Renal cell carcinoma (RCC) is frequently associated with paraneoplastic inflammatory syndrome (PIS). This study aimed at exploring the connections between the survival rate and specific gene alterations and the potential mechanism. We retrospectively studied 69 surgical RCC cases from August 2014 to February 2016, including 18 cases of clear cell RCC (ccRCC) demonstrating elevated pretreatment serum C-reactive protein (CRP, Group A). Twelve of the 18 cases were symptomized with febrile episode. We also selected 49 cases of ccRCC with normal pretreatment CRP (Group B). Using 22 microsatellite markers, we compared the incidence of loss of heterozygosity (LOH) between Group A and Group B. All statistical tests are two-sided. The 3p LOH was common in both Group A (89%) and Group B (92%). The frequency of 14q LOH in Group A (16 of 18) was higher than Group B (4 of 49, χ2 = 40.97 P < 0.0001). The 3p and 14q LOH were the characteristics of ccRCC with elevated acute phase reactants, including PIS, regardless of the presence of metastasis. On the contrary, 14q LOH was a rare genomic alternation in advanced-staged ccRCC without PIS. The overall survival of patients with elevated CRP (33.3%) was lower than its counterparts (6.1%, hazard ratio=1.852, P < 0.0001) in Kaplan-Meier curve. The results imply that the disruption of a 14q gene(s) might result in not only the inflammatory manifestations in the tumor host but also the poor survival rate as well. The isolation of the gene(s) on 14q might be a vital goal in the treatment of PIS-associated RCC.
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影响因子：
7.4
作者：
Quandt D;Jasinski-Bergner S;Müller U;Schulze B;Seliger B
通讯作者：
Seliger B
影响因子：
6.4
作者：
Nagy, A;Buzogany, I;Kovacs, G
通讯作者：
Kovacs, G
DOI：
10.1111/j.1365-2362.2007.01806.x
发表时间：
2007-06-01
影响因子：
5.5
作者：
Huang, J. S.;Huang, C. J.;Lin, C. M.
通讯作者：
Lin, C. M.
DOI：
10.1093/bfgp/elm007
发表时间：
2007-01-01
期刊：
Briefings in Functional Genomics & Proteomics
影响因子：
--
作者：
Angeloni, Debora
通讯作者：
Angeloni, Debora
影响因子：
6.5
作者：
Cordano, P;Lake, A;Jarrett, RF
通讯作者：
Jarrett, RF