pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory.
pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory.
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DOI：
10.3389/fbioe.2022.983677
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发表时间：
2022
影响因子：
5.7
通讯作者：
He, Yong
中科院分区：
文献类型：
--
作者：
Dou, Yuanyao;Zhang, Yimin;Lin, Caiyu;Han, Rui;Wang, Yubo;Wu, Di;Zheng, Jie;Lu, Conghua;Tang, Liling;He, Yong
关键词：
多组分集成在一个单一的治疗诊断纳米系统中实现治疗和诊断已经引起了医学研究者的极大研究兴趣。本研究的目的是构建一种新的治疗诊断纳米平台铁氧体和氧化铈共同设计的介孔二氧化硅纳米粒子（Fe/Ce-MSN）的抗氧化剂，通过一个简单的金属Fe/Ce共掺杂的方法在MSN框架。所得的Fe 3 +-掺入的基于二氧化铈的MSN纳米颗粒具有比仅二氧化铈纳米颗粒所揭示的那些更高的Ce 3 +-至-Ce 4+比率。结果表明，Fe/Ce-MSN纳米粒子对活性氧（ROS）具有良好的清除能力，这可能是由于纳米粒子中Ce 3+含量的增加提高了超氧化物歧化酶（SOD）模拟物的活性，而Fe 3+的引入则保持了过氧化氢酶（CAT）模拟物的活性。Fe/Ce-MSN的快速生物降解对炎症微环境的温和酸性敏感，可加速Fe/Ce离子的释放，释放的Fe离子可增强炎症部位的T2加权磁共振成像。PEG化的Fe/Ce-MSN纳米颗粒在体外细胞模型中通过清除过度产生的细胞内ROS显著减弱ROS诱导的炎症、氧化应激和巨噬细胞凋亡。更重要的是，Fe/Ce-MSN-PEG纳米粒在体外通过抑制脂多糖（LPS）诱导的肿瘤坏死因子-α（TNF-α）和白细胞介素-1 β（IL-1β）水平的表达而表现出显著的抗炎作用。此外，它可以促进巨噬细胞从促炎M1表型向抗炎M2表型极化。因此，新的pH响应性治疗诊断纳米平台显示出对炎症和氧化应激相关疾病治疗的巨大希望。
Multiple component integration to achieve both therapy and diagnosis in a single theranostic nanosystem has aroused great research interest in the medical investigator. This study aimed to construct a novel theranostic nanoplatform ferrite and ceria co-engineered mesoporous silica nanoparticles (Fe/Ce-MSN) antioxidant agent though a facile metal Fe/Ce-codoping approach in the MSN framework. The resulted Fe3+-incorporated ceria-based MSN nanoparticles possessing a higher Ce3+-to-Ce4+ ratio than those revealed by ceria-only nanoparticles. The as-prepared Fe/Ce-MSN nanoparticles exhibited an excellent efficiency in scavenging reactive oxygen species (ROS), which is attributed to improving the superoxide dismutase (SOD) mimetics activity by increasing Ce3+ content and maintaining a higher activity of catalase (CAT) mimetics via including ferrite ion in nanoparticles. The fast Fe/Ce-MSN biodegradation, which is sensitive to the mild acidic microenvironment of inflammation, can accelerate Fe/Ce ion release, and the freed Fe ions enhanced T2-weighted magnetic resonance imaging in the inflammation site. PEGylated Fe/Ce-MSN nanoparticles in vitro cell models significantly attenuated ROS-induced inflammation, oxidative stress, and apoptosis in macrophages by scavenging overproduced intracellular ROS. More importantly, Fe/Ce-MSN-PEG NPs exhibited significant anti-inflammatory effects by inhibiting lipopolysaccharide (LPS)-induced expression of tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) levels in vitro. Additionally, it can promote the macrophages polarization of pro-inflammatory M1 phenotype towards an anti-inflammatory M2 phenotype. Thus, the novel pH-responsive theranostic nanoplatform shows great promise for inflammation and oxidative stress-associated disease treatment.
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