PEGylated nanoceria as radical scavenger with tunable redox chemistry.
PEGylated nanoceria as radical scavenger with tunable redox chemistry.
复制标题
DOI：
10.1021/ja9051087
复制
发表时间：
2009-10-14
影响因子：
15
通讯作者：
Seal, Sudipta
中科院分区：
文献类型：
--
作者：
Karakoti, Ajay S.;Singh, Sanjay;Kumar, Amit;Malinska, Maura;Kuchibhatla, Satyanarayana V. N. T.;Wozniak, Krzysztof;Self, William T.;Seal, Sudipta
我们报道了在基于聚乙二醇（PEG）的溶液中直接合成氧化铈纳米颗粒（CNP），具有有效的自由基清除性能。在PEG中合成CNP证明了通过UV-可见光谱表征的浓度依赖性（PEG）氧化还原活性。聚乙二醇化的CNPs作为有效的自由基清除剂，与裸纳米氧化铈相比，在不同浓度的聚乙二醇中合成的CNPs的超氧化物歧化酶（SOD）活性并未降低。除了超氧化物，PEG化纳米氧化铈也表现出对过氧化物自由基的淬灭。据观察，与过氧化氢的反应导致由PEG的浓度控制的电荷转移复合物的形成。电荷转移复合物的稳定性提供了CNP的可调氧化态。该复合物的稳定性影响CNP的活性3+氧化态的再生能力。将PEG化CNP的细胞活力以及SOD活性与裸CNP的细胞活力以及SOD活性进行比较，并概述差异。
We report the direct synthesis of cerium oxide nanoparticles (CNPs) in polyethylene glycol (PEG) based solutions with efficient radical scavenging properties. Synthesis of CNPs in PEG demonstrated a concentration dependent (of PEG) redox activity characterized by UV−visible spectroscopy. PEGylated CNPs acted as efficient radical scavengers, and superoxide dismutase (SOD) activity of CNPs synthesized in various concentration of PEG did not reduce compared to bare nanoceria. In addition to superoxide, PEGylated nanoceria demonstrated quenching of peroxide radicals as well. It was observed that the reaction with hydrogen peroxide leads to the formation of a charge transfer complex governed by the concentration of PEG. The stability of the charge transfer complex provides the tunable oxidation state of CNPs. The stability of this complex influences the regenerative capacity of the active 3+ oxidation state of CNPs. The cell viability as well as SOD activity of PEGylated CNPs is compared to those of bare CNPs, and the differences are outlined.
登录
查看更多内容
影响因子：
6.2
作者：
Rogers, RD;Zhang, JH;Bauer, CB
通讯作者：
Bauer, CB
影响因子：
2.7
作者：
Uekawa, N;Ueta, M;Kakegawa, K
通讯作者：
Kakegawa, K
影响因子：
14
作者：
Heckert, Eric G.;Karakoti, Ajay S.;Self, William T.
通讯作者：
Self, William T.
影响因子：
10.8
作者：
Niu, Jianli;Azfer, Asim;Kolattukudy, Pappachan E.
通讯作者：
Kolattukudy, Pappachan E.
影响因子：
5.5
作者：
Tsai, Yi-Yang;Oca-Cossio, Jose;Sigmund, Wolfgang
通讯作者：
Sigmund, Wolfgang