Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration.
Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration.
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DOI：
10.9758/cpn.2014.12.1.31
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Hashimoto K
中科院分区：
文献类型：
--
作者：
Ma M;Ren Q;Zhang JC;Hashimoto K
越来越多的证据表明，炎症在抑郁症的病理生理学中起着重要作用。三磷酸腺苷（ATP）敏感的P2 X7受体（P2 X7 R）在炎症引起的小胶质细胞活化中起着至关重要的作用。染料亮蓝G（BBG）是P2 X7 R拮抗剂。本研究探讨了BBG是否在炎症诱导的抑郁症模型中显示出抗抑郁作用。本研究观察了BBG（12.5、25和50 mg/kg）对细菌内毒素脂多糖（LPS; 0.5 mg/kg）诱导的小鼠血清肿瘤坏死因子-α（TNF-α）水平的影响，以及BBG（50 mg/kg）对悬尾试验（TST）和强迫游泳试验（FST）中抑郁样行为的影响。BBG（12.5、25或50 mg/kg）预处理显著阻断LPS（0.5 mg/kg）单次给药后血清TNF-α水平的升高。此外，BBG（50 mg/kg）显着减弱LPS（0.5 mg/kg）给药后TST和FST不动时间的增加。结果表明，BBG对LPS诱导的小鼠具有抗炎和抗抑郁作用。因此，P2 X7 R拮抗剂是治疗炎症相关抑郁症的潜在药物。
Accumulating evidence suggests that inflammation plays a role in the pathophysiology of major depression. The adenosine triphosphate (ATP)-sensitive P2X7 receptor (P2X7R) plays a crucial role in microglial activation caused by inflammation. The dye brilliant blue G (BBG) is a P2X7R antagonist. This study examined whether BBG shows antidepressant effects in an inflammation-induced model of depression. We examined the effects of BBG (12.5, 25, or 50 mg/kg) on serum tumor necrosis factor-α (TNF-α) levels after administering the bacterial endotoxin lipopolysaccharide (LPS; 0.5 mg/kg) and the effects of BBG (50 mg/kg) on depression-like behavior in the tail-suspension test (TST) and forced swimming test (FST). Pretreatment with BBG (12.5, 25, or 50 mg/kg) significantly blocked the increase in serum TNF-α levels after a single dose of LPS (0.5 mg/kg). Furthermore, BBG (50 mg/kg) significantly attenuated the increase in immobility time in the TST and FST after LPS (0.5 mg/kg) administration. The results suggest that BBG has anti-inflammatory and antidepressant effects in mice after LPS administration. Therefore, P2X7R antagonists are potential therapeutic drugs for inflammation-related major depression.
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DOI：
10.1523/jneurosci.3295-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clark AK;Staniland AA;Marchand F;Kaan TK;McMahon SB;Malcangio M
通讯作者：
Malcangio M
DOI：
10.1002/ajmg.b.30799
发表时间：
2009-03-05
影响因子：
2.8
作者：
Hejjas, Krisvina;Szekely, Anna;Nemoda, Zsofia
通讯作者：
Nemoda, Zsofia
影响因子：
3.6
作者：
Jiang, LH;Mackenzie, AB;Surprenant, A
通讯作者：
Surprenant, A
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
DOI：
10.1002/ajmg.b.30952
发表时间：
2009-10-05
影响因子：
2.8
作者：
Grigoroiu-Serbanescu, Maria;Herms, Stefan;Cichon, Sven
通讯作者：
Cichon, Sven