Superior logistic model for decay of Ca2+ transient and isometric relaxation force curve in rabbit and mouse papillary muscles.
Superior logistic model for decay of Ca2+ transient and isometric relaxation force curve in rabbit and mouse papillary muscles.
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兔和小鼠乳头肌 Ca2 瞬时和等长松弛力曲线衰减的高级逻辑模型。
DOI：
10.1536/ihj.48.215
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发表时间：
2007
影响因子：
1.5
通讯作者：
S. Kurihara
中科院分区：
文献类型：
--
作者：
J. Mizuno;M. Otsuji;K. Takeda;Yoshitsugu Yamada;Hideko Arita;K. Hanaoka;Shuta Hirano;Y. Kusakari;S. Kurihara
A decrease in myocardial intracellular calcium concentration ([Ca(2+)](i)) precedes relaxation, and a monoexponential function is typically used for fitting the decay of the Ca(2+) transient. However, a logistic function has been shown to be a better fit for the relaxation force curve, compared to the conventional monoexponential function. In the present study, we compared the logistic and monoexponential functions for fitting the [Ca(2+)](i) declines, which were measured using the aequorin method, and isometric relaxation force curves at 4 different onsets: the minimum time-derivative of [Ca(2+)](i) (d[Ca(2+)](i)/dt (min)) and force (dF/dt(min)), and the 10%, 20% and 30% lower [Ca(2+)](i) levels and forces over the data-sampling period in 7 isolated rabbit right ventricular and 15 isolated mouse left ventricular papillary muscles. Logistic functions were significantly superior for fitting the [Ca(2+)] (i) declines and relaxation force curves, compared to monoexponential functions. Changes in the normalized logistic [Ca(2+)] (i) decline and relaxation force time constants at the delayed onsets relative to their 100% values at d[Ca(2+)] (i)/dt(min) and dF/dt(min) were significantly smaller than the changes in the normalized monoexponential time constants. The ratio of the logistic relaxation force time constant relative to the logistic [Ca(2+)](i) decline time constant was significantly smaller in mouse than in rabbit. We conclude that the logistic function more reliably characterizes the [Ca(2+)](i) decline and relaxation force curve at any onset, irrespective of animal species. Simultaneous analyses using the logistic model for decay of the Ca(2+) transient and myocardial lusitropism might be a useful strategy for analysis of species-specific myocardial calcium handling.
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影响因子：
5
作者：
Dobrunz,LE;Berman,MR
通讯作者：
Berman,MR
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DOI：
10.1172/jci117101
发表时间：
1994
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Camacho,SA;Brandes,R;Figueredo,VM;Weiner,MW
通讯作者：
Weiner,MW
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DOI：
10.1152/ajpheart.1996.271.1.h228
发表时间：
1996
期刊：
The American journal of physiology
影响因子：
--
作者：
Chang,KC;Schreur,JH;Weiner,MW;Camacho,SA
通讯作者：
Camacho,SA
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影响因子：
24
作者：
Senzaki,H;Fetics,B;Chen,CH;Kass,DA
通讯作者：
Kass,DA
影响因子：
5.5
作者：
ALLEN, DG;KURIHARA, S
通讯作者：
KURIHARA, S